Document Detail


Placental transfer of SSRI and SNRI antidepressants and effects on the neonate.
MedLine Citation:
PMID:  19452377     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: We investigated placental transfer and neurobehavioural effects in neonates exposed to citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine or sertraline (SSRI's), or to venlafaxine (an SNRI). METHODS: Women receiving antidepressants during pregnancy and their neonates were studied. Cord and maternal drug concentrations were measured at birth and in the neonates plasma on day 3. Neonates were also assessed using a range of neurobehavioral tests and compared to controls. RESULTS: Median cord/maternal distribution ratio was 0.7-0.86 (range) for SSRIs, 0.72 for the SNRI venlafaxine and 1.08 for the O-desmethyl metabolite. Neonatal abstinence scores were significantly higher (p<0.05) in exposed infants than controls on day 1. Brazelton scores for habituation, social-interactive, motor and autonomic clusters, and serotonin scores were significantly greater (p<0.05) in exposed infants. DISCUSSION: Transfer of SSRIs and SNRIs across the placenta was substantial. Neonates developed mild behavioral symptoms in the early perinatal period but these were self-limiting and similar for both SSRIs and the SNRI venlafaxine.
Authors:
J Rampono; K Simmer; K F Ilett; L P Hackett; D A Doherty; R Elliot; C H Kok; A Coenen; T Forman
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-18
Journal Detail:
Title:  Pharmacopsychiatry     Volume:  42     ISSN:  1439-0795     ISO Abbreviation:  Pharmacopsychiatry     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-19     Completed Date:  2009-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8402938     Medline TA:  Pharmacopsychiatry     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  95-100     Citation Subset:  IM    
Affiliation:
Department of Psychological Medicine, King Edward Memorial Hospital for Women, Subiaco, Australia.
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MeSH Terms
Descriptor/Qualifier:
Antidepressive Agents, Second-Generation / adverse effects*,  blood,  pharmacokinetics*
Depressive Disorder / drug therapy*
Female
Fetal Blood
Humans
Infant Behavior / drug effects
Infant, Newborn
Maternal-Fetal Exchange*
Neonatal Abstinence Syndrome*
Pregnancy
Pregnancy Outcome
Prospective Studies
Serotonin Uptake Inhibitors / adverse effects*,  blood,  pharmacokinetics*
Chemical
Reg. No./Substance:
0/Antidepressive Agents, Second-Generation; 0/Serotonin Uptake Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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