| Placental protein-13 and pregnancy-associated plasma protein-a as first trimester screening markers for hypertensive disorders and small for gestational age outcomes. | |
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MedLine Citation:
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PMID: 20701472 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective. To investigate the role of placenta protein 13 (PP13) and pregnancy-associated plasma protein-A (PAPP-A) in hypertensive disorders and small for gestational age (SGA) during first trimester of pregnancy. Methods. In this case-control study, first trimester serum samples (11(+0) to 13(+6) weeks) were retrieved from frozen storage of which 452 were from normal pregnancies and 47 samples were identified to have pregnancies with at least one of the following adverse outcomes: SGA, preeclampsia (PE), hemolysis, elevated liver enzymes, and low platelets (HELLP), or gestational hypertension (GH). PP13 concentrations were measured by a new AutoDELFIA method. Levels of PAPP-A were measured for a first trimester screening program using Kryptor analyzer. Results. First trimester levels of PAPP-A are significantly lower in cases of SGA, PE, and most subgroups including HELLP. Levels of PP13 were not found to differ between control and affected pregnancies. Conclusion. PP13 needs to be studied further as our results contrast the majority of previous studies. |
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Authors:
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Anastasia Stamatopoulou; Nicholas J Cowans; Elisabet Matwejew; Constantine von Kaisenberg; Kevin Spencer |
Publication Detail:
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Type: Journal Article Date: 2010-08-11 |
Journal Detail:
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Title: Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy Volume: 30 ISSN: 1525-6065 ISO Abbreviation: Hypertens Pregnancy Publication Date: 2011 |
Date Detail:
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Created Date: 2011-09-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9421297 Medline TA: Hypertens Pregnancy Country: England |
Other Details:
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Languages: eng Pagination: 384-95 Citation Subset: IM |
Affiliation:
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Prenatal Research Unit, Clinical Biochemistry Department, King George Hospital , Goodmayes , UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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