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Placental Pathologies on fetal MRI are associated with high impairment rates: a prospective long-term outcome study.
MedLine Citation:
PMID:  25053195     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective Placental anomalies visualized at midgestation by MRI are shown to be related to pregnancy outcome. We performed a prospective cohort study to investigate the influence of placental pathologies diagnosed with fetal MRI on long-term neurodevelopmental outcome. Methods In our hospital-based, cross-sectional study, all fetal MRI examinations of pregnancies with vascular placental pathology (i.e., infarction with/without hemorrhage, subchorionic thrombi/hemorrhages, intervillous thrombi/hemorrhages, or retroplacental hematoma) between 2003 and 2007 were included. The extent of the pathology was expressed as the percentage of abnormality related to the whole placental volume. Pathohistological reports were correlated to MRI findings. Infants were prospectively investigated using Bayley developmental scales at the age of 2 to 3.5 years. Impairment was categorized as a Bayley scale two SDs below normal (<85 points). Results There were 31 singletons and 25 offspring of multiple pregnancies included in the analyses. Impairment rates were 32.2% in singletons, and 32.0% in multiple births. No correlation between neuro/motordevelopmental outcome at 2- 3.5 years and the type, extent, or gestational week at the time of diagnoses of placental vascular pathologies was found. Conclusion The long-term outcome of children with vascular placental pathologies on fetal MRI was associated with a high impairment rate after 2-3.5 years, both on motor- and neurodevelopmental Bayley scales. Neurological impairment did not correlate with the extent of placental involvement, IUGR, GA at birth, or multiple state.
Authors:
Nina Linduska; Antonia Knoezinger; Sabine Dekan; Michael Weber; Michael Hayde; Daniela Prayer; Agnes Grill
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-23
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-18     Citation Subset:  -    
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