| Placental interleukin-15 expression in recurrent miscarriage. | |
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MedLine Citation:
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PMID: 20560915 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PROBLEM: Cytokines play a fundamental role at the feto-maternal interface. A dysregulation of the cytokine profile could be linked with fetal rejection. This study investigated differences in the expression of the Th1 cytokine interleukin-15 (IL-15) of normal and disturbed pregnancy. METHOD OF STUDY: Analysis of IL-15 expression by immunohistochemistry and real-time RT-PCR in placental tissue from normal pregnancies, spontaneous miscarriage and recurrent miscarriage (RM) was performed. RESULTS: Expression of IL-15 was upregulated on mRNA and protein level in the placenta of miscarriage patients, especially in patients with RM. Immunohistochemistry and immunofluorescence double staining revealed extravillous trophoblast cells (EVT) as IL-15-expressing cells. Staining results were confirmed by real-time PCR (TaqMan). CONCLUSION: Increased expression of IL-15 in the decidua of patients with RM may be linked to disturbed implantation and vascularization with consecutive placental and fetal rejection. |
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Authors:
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Bettina Toth; Thomas Haufe; Christoph Scholz; Christina Kuhn; Klaus Friese; Maria Karamouti; Antonis Makrigiannakis; Udo Jeschke |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 64 ISSN: 1600-0897 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: Denmark |
Other Details:
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Languages: eng Pagination: 402-10 Citation Subset: IM |
Copyright Information:
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© 2010 John Wiley & Sons A/S. |
Affiliation:
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Department of Gynecological Endocrinology and Fertility Disorders, Ruprechts-Karls University, Heidelberg, Germany. Bettina.toth@med.uni-heidelberg.de |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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