| Placental histopathologic changes associated with subclinical malaria infection and its impact on the fetal environment. | |
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MedLine Citation:
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PMID: 21036823 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Microscopic examination of placental tissue can provide an accurate assessment of malaria infection during pregnancy. In this cross-sectional study of 193 women in Iquitos, Peru, 1.0% and 6.6% had parasites in the peripheral blood as detected by microscopy and polymerase chain reaction, respectively. However, 22% had placental malaria pigment indicating past, subclinical infections. Placental tissues with pigment from 24 cases were matched by gravidity and month of delivery to 24 controls and histopathologically examined. Cases had significantly higher number of monocytes in the intervillous space (44.7 versus 25.5; P = 0.012). Pigmented monocytes in fetal vessels were present in 33.3% of cases. This study demonstrated that subclinical malarial infection occurred frequently in pregnant women and is associated with increased presence of monocytes in the placenta. Pigmented monocytes in fetal vessels suggest parasites can breach the placental barrier and enter the fetal circulation. |
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Authors:
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Falgunee K Parekh; Billie B Davison; Dionicia Gamboa; Jean Hernandez; Oralee H Branch |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of tropical medicine and hygiene Volume: 83 ISSN: 1476-1645 ISO Abbreviation: Am. J. Trop. Med. Hyg. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-01 Completed Date: 2010-11-30 Revised Date: 2011-11-07 |
Medline Journal Info:
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Nlm Unique ID: 0370507 Medline TA: Am J Trop Med Hyg Country: United States |
Other Details:
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Languages: eng Pagination: 973-80 Citation Subset: AIM; IM |
Affiliation:
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Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Case-Control Studies Cross-Sectional Studies Female Hemeproteins / analysis Humans Malaria, Falciparum / blood, epidemiology, pathology* Malaria, Vivax / blood, epidemiology, pathology* Monocytes / pathology Parasitemia / blood Peru / epidemiology Pigments, Biological / analysis Placenta / chemistry, parasitology, pathology* Pregnancy Pregnancy Complications, Parasitic / blood, epidemiology, pathology* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R01AL064831//PHS HHS; UR3/CCU 418652//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Hemeproteins; 0/Pigments, Biological; 39404-00-7/hemozoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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