Document Detail


Placental Growth Factor (PlGF): a key to optimizing fetal growth.
MedLine Citation:
PMID:  23330778     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract The needs of the uterus and the fetus for provision of nutrients and oxygen, supplied by the blood flow, are understandably extremely high, with the circulatory system playing the most important role in this action. Abnormal vascular growth and transformation that create a high vessel resistance network have been associated with various pregnancy pathologies, including miscarriage, Small for Gestational Age Fetuses (SGA) with or without preeclampsia, and Intrauterine Growth Restriction (IUGR). Placental Growth Factor (PlGF) has a major role in vasculogenesis and angiogenesis in human placenta. Low concentrations of PlGF and high concentrations of its inhibitor soluble Fms-like tyrosine kinase-1 (sFlt-1) are linked with impaired angiogenesis and placental development, leading to the above pregnancy complications. The activity of Vascular Endothelial Growth Factor (VEGF), which is the most potent of all angiogenic mediators, is partly modulated by PlGF. Although the mechanisms via which PlGF exerts its various effects are still under investigation, we herein discuss the known actions exerted by this major mediator together with its results on fetal growth.
Authors:
Nikolaos Vrachnis; Emmanouil Kalampokas; Stavros Sifakis; Nikolaos Vitoratos; Theodoros Kalampokas; Demetrios Botsis; Zoe Iliodromiti
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-18
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
2nd Department of Obstetrics and Gynecology, University of Athens Medical School, Greece.
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