Document Detail

Placental Findings in Singleton Stillbirths.
MedLine Citation:
PMID:  24402599     Owner:  NLM     Status:  Publisher    
OBJECTIVE:: To compare placental lesions for stillbirth cases and live birth controls in a population-based study.
METHODS:: Pathologic examinations were performed on placentas from singleton pregnancies using a standard protocol. Data were analyzed overall and within gestational age groups at delivery.
RESULTS:: Placentas from 518 stillbirths and 1,200 live births were studied. Single umbilical artery was present in 7.7% of stillbirths and 1.7% of live births, velamentous cord insertion was present in 5% of stillbirths and 1.1% of live births, diffuse terminal villous immaturity was present in 10.3% of stillbirths and 2.3% of live births, inflammation (eg, acute chorioamnionitis of placental membranes) was present in 30.4% of stillbirths and 12% of live births, vascular degenerative changes in chorionic plate were present in 55.7% of stillbirths and 0.5% of live births, retroplacental hematoma was present in 23.8% of stillbirths and 4.2% of live births, intraparenchymal thrombi was present in 19.7% of stillbirths and 13.3% of live births, parenchymal infarction was present in 10.9% of stillbirths and 4.4% of live births, fibrin deposition was present in 9.2% of stillbirths and 1.5% of live births, fetal vascular thrombi was present in 23% of stillbirths and 7% of live births, avascular villi was present in 7.6% of stillbirths and 2.0% of live births, and hydrops was present in 6.4% of stillbirths and 1.0% of live births. Among stillbirths, inflammation and retroplacental hematoma were more common in placentas from early deliveries, whereas thrombotic lesions were more common in later gestation. Inflammatory lesions were especially common in early live births.
CONCLUSIONS:: Placental lesions were highly associated with stillbirth compared with live births. All lesions associated with stillbirth were found in live births but often with variations by gestational age at delivery. Knowledge of lesion prevalence within gestational age groups in both stillbirths and live birth controls contributes to an understanding of the association between placental abnormality and stillbirth. LEVEL OF EVIDENCE:: II.
Halit Pinar; Robert L Goldenberg; Matthew A Koch; Josefine Heim-Hall; Hal K Hawkins; Bahig Shehata; Carlos Abramowsky; Corette B Parker; Donald J Dudley; Robert M Silver; Barbara Stoll; Marshall Carpenter; George Saade; Janet Moore; Deborah Conway; Michael W Varner; Carol J R Hogue; Donald R Coustan; Elena Sbrana; Vanessa Thorsten; Marian Willinger; Uma M Reddy
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-1-7
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  -     ISSN:  1873-233X     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-1-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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