Document Detail


Placental Expression of Peroxisome Proliferator-Activated Receptor γ (PPARγ): Relation to Placental and Fetal Growth.
MedLine Citation:
PMID:  22689692     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background and Objective:The nuclear receptor peroxisome proliferator activated receptor γ (PPARγ) contributes to placental development and thus to the maternofetal transfer of oxygen and nutrients that allow for prenatal growth. We tested the hypothesis that placental PPARγ expression relates to placental and fetal growth.Design and Study Population:Placentas (n = 116) were collected at term delivery of singleton infants who were born small- (SGA), appropriate- (AGA), or large-for-gestational-age (LGA) (n = 32 SGA, 55 AGA, and 29 LGA). Placentas and newborns were weighed at birth. Real-time PCR was used to assess placental expression of PPARγ as compared to the housekeeping gene GAPDH.Results:PPARγ expression in placentas from AGA and LGA infants was nearly 2-fold higher than in placentas from SGA infants. Placental PPARγ expression associated positively to placental and/or fetal weight at birth, particularly within the SGA subpopulation (P = 0.001).Conclusion:PPARγ expression was found to be low in placentas of SGA fetuses and to associate positively to fetal and placental weights within this subpopulation.
Authors:
Marta Díaz; Judit Bassols; Abel López-Bermejo; Maria Dolores Gómez-Roig; Francis de Zegher; Lourdes Ibáñez
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-11
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  -     ISSN:  1945-7197     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Endocrinology (L.I.) and Obstetrics and Gynecology (M.D.G.-R.), Hospital Sant Joan de Déu, University of Barcelona, 08950 Esplugues, Barcelona, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (M.D., L.I.), Instituto de Salud Carlos III, 28029 Madrid, Spain; Department of Pediatrics (J.B., A.L.-B.), Dr. Josep Trueta Hospital, 17007 Girona, Spain; Girona Institute for Biomedical Research (J.B., A.L.-B.), 17007 Girona, Spain; and University of Leuven (F.d.Z.), 3000 Leuven, Belgium.
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