Document Detail


Placental amino acid transport and placental leptin resistance in pregnancies complicated by maternal obesity.
MedLine Citation:
PMID:  20609473     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
MATERIALS AND METHODS: Seven lean, BMI at entry 22.4, and seven obese, BMI at entry 31.5 (p < 0.001), pregnant women were studied at 39 weeks. We measured baseline and leptin-stimulated placental system A sodium-dependent neutral amino acid transporter (SNAT) activity, placental immunoreactive protein expression of SNAT, leptin and leptin receptor, and maternal and fetal plasma leptin concentrations, with significance set at p <or= 0.05. The primary outcome measure was placental SNAT activity.
RESULTS: The obese group had decreased placental SNAT activity (p = 0.005), maternal hyperleptinemia (p = 0.01) and decreased syncytiotrophoblast expression of leptin receptor (p = 0.01) and SNAT-4 (p < 0.001). Placental amino acid uptake was significantly stimulated by leptin in the lean group as compared to the obese group. Maternal weight gain and offspring birth weights were not different between groups.
CONCLUSION: Maternal obesity was accompanied by decreased placental SNAT activity associated with maternal hyperleptinemia and placental leptin resistance in spite of appropriate maternal weight gain and normally grown neonates. These findings suggest altered placental function that may have clinical implications in obese pregnant women.
Authors:
D M Farley; J Choi; D J Dudley; C Li; S L Jenkins; L Myatt; P W Nathanielsz
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-07-07
Journal Detail:
Title:  Placenta     Volume:  31     ISSN:  1532-3102     ISO Abbreviation:  Placenta     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-06     Completed Date:  2010-11-24     Revised Date:  2011-01-11    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  England    
Other Details:
Languages:  eng     Pagination:  718-24     Citation Subset:  IM    
Affiliation:
Center for Pregnancy and Newborn Research, Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Texas Health Science Center at San Antonio, Texas 78229-3900, USA. farleyd3@uthscsa.edu
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Transport System A / metabolism*
Body Mass Index
Female
Humans
Immunohistochemistry
Infant, Newborn
Insulin / blood
Leptin / blood*
Obesity / metabolism*
Placenta / metabolism*
Pregnancy
Pregnancy Complications / metabolism*
Grant Support
ID/Acronym/Agency:
HD 21350-17/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Amino Acid Transport System A; 0/Leptin; 11061-68-0/Insulin

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