| Placenta-bound immunoglobulins. | |
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MedLine Citation:
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PMID: 92319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Low pH eluates were prepared from trophoblasts derived from 8 term human placentas. A qualitative analysis for immunoglobulins revealed the presence of IgG, IgA, and IgM in these eluates. IgC-rich fractions were obtained by DEAE-cellulose chromatography of ammonium sulfate-concentrated eluates. These fractions were able to neutralize, in vitro, the catalytic activity of reverse transcriptases (RT) from several retroviruses. RT from baboon endogenous virus (BEV) seemed to be more susceptible to the neutralizing activity of some eluates. This was in contrast to RT from feline leukemia virus (FeLV) which were neutralized by eluates of leukocytes from chronic myelogenous leukemia. In contrast to previous and present results with purified IgG from leukemic leukocytes, the purified IgG from placenta eluates was incapable of RT neutralization. However, such purified IgG fractions inhibited mixed lymphocyte reactions. |
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Authors:
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A Jurjus; D A Wheeler; R C Gallo; I P Witz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Arthritis and rheumatism Volume: 22 ISSN: 0004-3591 ISO Abbreviation: Arthritis Rheum. Publication Date: 1979 Nov |
Date Detail:
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Created Date: 1980-01-28 Completed Date: 1980-01-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370605 Medline TA: Arthritis Rheum Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1308-13 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Female Humans Hydrogen-Ion Concentration Immunoglobulin G / analysis* Leukemia, Myeloid / immunology Lymphocyte Culture Test, Mixed Neutralization Tests Placenta / immunology* Pregnancy RNA-Directed DNA Polymerase / metabolism Retroviridae / enzymology Trophoblasts / immunology, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin G; EC 2.7.7.49/RNA-Directed DNA Polymerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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