Document Detail

Placenta-bound immunoglobulins.
MedLine Citation:
PMID:  92319     Owner:  NLM     Status:  MEDLINE    
Low pH eluates were prepared from trophoblasts derived from 8 term human placentas. A qualitative analysis for immunoglobulins revealed the presence of IgG, IgA, and IgM in these eluates. IgC-rich fractions were obtained by DEAE-cellulose chromatography of ammonium sulfate-concentrated eluates. These fractions were able to neutralize, in vitro, the catalytic activity of reverse transcriptases (RT) from several retroviruses. RT from baboon endogenous virus (BEV) seemed to be more susceptible to the neutralizing activity of some eluates. This was in contrast to RT from feline leukemia virus (FeLV) which were neutralized by eluates of leukocytes from chronic myelogenous leukemia. In contrast to previous and present results with purified IgG from leukemic leukocytes, the purified IgG from placenta eluates was incapable of RT neutralization. However, such purified IgG fractions inhibited mixed lymphocyte reactions.
A Jurjus; D A Wheeler; R C Gallo; I P Witz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  22     ISSN:  0004-3591     ISO Abbreviation:  Arthritis Rheum.     Publication Date:  1979 Nov 
Date Detail:
Created Date:  1980-01-28     Completed Date:  1980-01-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1308-13     Citation Subset:  AIM; IM    
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MeSH Terms
Hydrogen-Ion Concentration
Immunoglobulin G / analysis*
Leukemia, Myeloid / immunology
Lymphocyte Culture Test, Mixed
Neutralization Tests
Placenta / immunology*
RNA-Directed DNA Polymerase / metabolism
Retroviridae / enzymology
Trophoblasts / immunology,  metabolism
Reg. No./Substance:
0/Immunoglobulin G; EC DNA Polymerase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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