Document Detail

Placenta analysis of prenatally diagnosed patients reveals early GAG storage in mucopolysaccharidoses II and VI.
MedLine Citation:
PMID:  21427013     Owner:  NLM     Status:  Publisher    
We analyzed placental tissue in one fetus with MPS II (iduronate sulphatase deficiency) and another with MPS VI (arylsulfatase B deficiency). Both were diagnosed prenatally, but families decided to continue pregnancies and placentas were collected at birth. We were able to demonstrate early storage of GAGs in both diseases by GAG measurement and microscopy analysis. Our results suggest that some alterations related to MPS storage, although not pronounced, may be observed in placental tissue of patients affected by MPS II and MPS VI.
Guilherme Baldo; Ursula Matte; Osvaldo Artigalas; Ida Vanessa Schwartz; Maira Graeff Burin; Erlane Ribeiro; Dafne Horovitz; Tatiana Pacheco Magalhaes; Milan Elleder; Roberto Giugliani
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-21
Journal Detail:
Title:  Molecular genetics and metabolism     Volume:  -     ISSN:  1096-7206     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9805456     Medline TA:  Mol Genet Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Gene Therapy Center, Hospital de Clinicas, Porto Alegre, Brazil; Postgraduate Program in Biological Sciences: Biochemistry, UFRGS, Porto Alegre, Brazil.
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