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Placenta-Derived Multipotent Cells Differentiate into Neuronal and Glial Cells In Vitro.
MedLine Citation:
PMID:  18092931     Owner:  NLM     Status:  Publisher    
Stem cells have great potential for clinical application because of their self-renewal property and ability to differentiate into many types of cells, but because there are ethical and biological limitations with current sources of stem cells, the search continues for more suitable sources of multipotent cells. We have reported previously on a population of multipotent cells isolated from the human term placenta, an ethically unproblematic and easily available source of tissue. These placenta-derived multipotent cells (PDMCs) can differentiate into lineages of mesenchymal tissues, including osteoblasts and adipocytes, as well as non-mesenchymal tissue of neuron-like cells. We further examined the ability of PDMCs to differentiate into all 3 types of neural cells-neurons, astrocytes, and oligodendrocytes-under various induction conditions, including retinoic acid (RA), 1-methyl-3-isobutylxanthine (IBMX), and co-culture with neonatal rat brain cells. PDMCs exhibited outgrowth of processes and the expression of neuron-specific molecules such as neuron-specific enolase upon induction. Co-culture with neonatal rat brain cells also induced neural differentiation. Our results indicate that PDMCs can be differentiated into neural cell types of the human nervous system upon exposure to RA, IBMX, or primary rat brain cells.
B Linju Yen; Chih-Cheng Chien; Yao-Chang Chen; Jen-Tse Chen; Jing-Shan Huang; Fa-Kung Lee; Hsing-I Huang
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2007-12-19
Journal Detail:
Title:  Tissue engineering     Volume:  -     ISSN:  1076-3279     ISO Abbreviation:  Tissue Eng.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505538     Medline TA:  Tissue Eng     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Stem Cell Research Center, National Health Research Institutes, Taipei, Taiwan.
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