Document Detail


Placement of an elastic biodegradable cardiac patch on a subacute infarcted heart leads to cellularization with early developmental cardiomyocyte characteristics.
MedLine Citation:
PMID:  22748493     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Placement of an elastic biodegradable patch onto a subacute myocardial infarct (MI) provides temporary elastic support that may act to effectively alter adverse left ventricular (LV) remodeling processes.
METHODS: Two weeks after permanent left coronary ligation in Lewis rats, the infarcted anterior wall was covered with polyester urethane urea (MI + PEUU; n = 15) or expanded polytetrafluoroethylene (MI + ePTFE; n = 15) patches, or had no implantation (MI + sham; n = 12). Eight weeks after surgery, cardiac function and histology were assessed.
RESULTS: The ventricular wall in the MI + ePTFE and MI + sham groups was composed of fibrous tissue, whereas PEUU implantation induced α-smooth muscle actin-positive muscle bundles coexpressing sarcomeric α-actinin and cardiac-specific troponin-T. This pattern of colocalization was also found in developing embryonic myocardium. Cardiac transcription factors Nkx-2.5 and GATA-4 were strongly expressed in the muscle bundles. In the MI + sham group, end-diastolic LV cavity area (EDA) increased and the percentage of fractional area change (%FAC) decreased. For ePTFE patched animals, both EDA and %FAC decreased. In contrast, with MI + PEUU patching, %FAC increased and EDA was maintained. With dobutamine-stress echocardiography, MI + PEUU patched LVs possessed contractile reserve significantly larger than the MI + sham group.
CONCLUSIONS: MI + PEUU patch implantation onto subacute infarcted myocardium induced muscle cellularization with characteristics of early developmental cardiomyocytes as well as providing a functional reserve.
Authors:
Kazuro L Fujimoto; Kimimasa Tobita; Jianjun Guan; Ryotaro Hashizume; Keisuke Takanari; Christina M Alfieri; Katherine E Yutzey; William R Wagner
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of cardiac failure     Volume:  18     ISSN:  1532-8414     ISO Abbreviation:  J. Card. Fail.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-03     Completed Date:  2012-10-24     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  585-95     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15219, USA.
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MeSH Terms
Descriptor/Qualifier:
Actins / metabolism
Animals
Animals, Newborn
Biocompatible Materials / administration & dosage*
Connexin 43 / metabolism
Echocardiography
Elasticity
Female
Fetus
Fibrosis
GATA4 Transcription Factor / genetics,  metabolism
Heart / embryology
Heart Ventricles / pathology
Homeodomain Proteins / genetics,  metabolism
Immunohistochemistry
Microscopy, Electron
Myocardial Infarction / pathology*,  therapy*
Myocardium / metabolism*,  pathology*
Polytetrafluoroethylene
Polyurethanes
RNA, Messenger / metabolism
Rats
Regeneration
Transcription Factors / genetics,  metabolism
Troponin T / metabolism
Ventricular Remodeling
Grant Support
ID/Acronym/Agency:
HL069368/HL/NHLBI NIH HHS; R01 HL069368/HL/NHLBI NIH HHS; UL1 RR024153/RR/NCRR NIH HHS; UL1 TR000005/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Actins; 0/Biocompatible Materials; 0/Connexin 43; 0/GATA4 Transcription Factor; 0/Homeodomain Proteins; 0/Nkx2-5 protein, mouse; 0/Polyurethanes; 0/RNA, Messenger; 0/Transcription Factors; 0/Troponin T; 0/polyetherurethane; 0/smooth muscle actin, rat; 9002-84-0/Polytetrafluoroethylene
Comments/Corrections

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