| Placement of an elastic biodegradable cardiac patch on a subacute infarcted heart leads to cellularization with early developmental cardiomyocyte characteristics. | |
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MedLine Citation:
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PMID: 22748493 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Placement of an elastic biodegradable patch onto a subacute myocardial infarct (MI) provides temporary elastic support that may act to effectively alter adverse left ventricular (LV) remodeling processes. METHODS: Two weeks after permanent left coronary ligation in Lewis rats, the infarcted anterior wall was covered with polyester urethane urea (MI + PEUU; n = 15) or expanded polytetrafluoroethylene (MI + ePTFE; n = 15) patches, or had no implantation (MI + sham; n = 12). Eight weeks after surgery, cardiac function and histology were assessed. RESULTS: The ventricular wall in the MI + ePTFE and MI + sham groups was composed of fibrous tissue, whereas PEUU implantation induced α-smooth muscle actin-positive muscle bundles coexpressing sarcomeric α-actinin and cardiac-specific troponin-T. This pattern of colocalization was also found in developing embryonic myocardium. Cardiac transcription factors Nkx-2.5 and GATA-4 were strongly expressed in the muscle bundles. In the MI + sham group, end-diastolic LV cavity area (EDA) increased and the percentage of fractional area change (%FAC) decreased. For ePTFE patched animals, both EDA and %FAC decreased. In contrast, with MI + PEUU patching, %FAC increased and EDA was maintained. With dobutamine-stress echocardiography, MI + PEUU patched LVs possessed contractile reserve significantly larger than the MI + sham group. CONCLUSIONS: MI + PEUU patch implantation onto subacute infarcted myocardium induced muscle cellularization with characteristics of early developmental cardiomyocytes as well as providing a functional reserve. |
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Authors:
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Kazuro L Fujimoto; Kimimasa Tobita; Jianjun Guan; Ryotaro Hashizume; Keisuke Takanari; Christina M Alfieri; Katherine E Yutzey; William R Wagner |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of cardiac failure Volume: 18 ISSN: 1532-8414 ISO Abbreviation: J. Card. Fail. Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-07-03 Completed Date: 2012-10-24 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 9442138 Medline TA: J Card Fail Country: United States |
Other Details:
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Languages: eng Pagination: 585-95 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15219, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Actins
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metabolism Animals Animals, Newborn Biocompatible Materials / administration & dosage* Connexin 43 / metabolism Echocardiography Elasticity Female Fetus Fibrosis GATA4 Transcription Factor / genetics, metabolism Heart / embryology Heart Ventricles / pathology Homeodomain Proteins / genetics, metabolism Immunohistochemistry Microscopy, Electron Myocardial Infarction / pathology*, therapy* Myocardium / metabolism*, pathology* Polytetrafluoroethylene Polyurethanes RNA, Messenger / metabolism Rats Regeneration Transcription Factors / genetics, metabolism Troponin T / metabolism Ventricular Remodeling |
| Grant Support | |
ID/Acronym/Agency:
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HL069368/HL/NHLBI NIH HHS; R01 HL069368/HL/NHLBI NIH HHS; UL1 RR024153/RR/NCRR NIH HHS; UL1 TR000005/TR/NCATS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Actins; 0/Biocompatible Materials; 0/Connexin 43; 0/GATA4 Transcription Factor; 0/Homeodomain Proteins; 0/Nkx2-5 protein, mouse; 0/Polyurethanes; 0/RNA, Messenger; 0/Transcription Factors; 0/Troponin T; 0/polyetherurethane; 0/smooth muscle actin, rat; 9002-84-0/Polytetrafluoroethylene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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