| Placebo effects on analgesia related to testosterone and premotor activation. | |
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MedLine Citation:
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PMID: 21546858 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Using functional magnetic resonance imaging, we tested whether graded placebo conditions could modulate the degree of placebo effect and brain activation patterns in study participants and whether the placebo effect could be influenced by hormones. Each participant was investigated under three conditions: the control (no placebo) condition, the low-placebo condition, and the high-placebo condition (HPC). Activations of the premotor areas, anterior cingulate cortex, and prefrontal cortex were stronger in the HPC compared with those in the control and low placebo conditions. The premotor areas were activated by increased testosterone levels under the HPC. These results suggest that testosterone may affect the brain activation and response to pain during a high-placebo response, with the data supported by brain imaging. |
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Authors:
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Jae Chan Choi; Do-Joon Yi; Bong Soo Han; Phil Hyu Lee; Ji Hyun Kim; Bo-Hyun Kim |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-4 |
Journal Detail:
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Title: Neuroreport Volume: - ISSN: 1473-558X ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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aDepartment of Anesthesiology and Pain Medicine, Brain Research Group, Institute of Basic Medical Science, Yonsei University Wonju College of Medicine bDepartment of Radiological Science, College of Health Science, Yonsei University, Gangwon-do, Wonju cDepartment of Psychology Yonsei University, Seodaemun-gu dDepartment of Neurology and Brain Research Institute, Yonsei University College of Medicine Seodaemon-ku eDepartment of Neurology, Korea University College of Medicine, Seoul fDepartment of Mathematics, Natural Sciences Chungnam National University, Yuseong-gu, Daejeon, South Korea. |
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