| Placebo effect in the treatment of angina pectoris. | |
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MedLine Citation:
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PMID: 309264 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The interference of placebo effect in the treatment of angina pectoris has been studied in a group of patients with stable angina pectoris, selected on the basis of normal electrocardiogram at rest and a pathologic ergometric electrocardiographic test. It was found that the patients could be divided, according to the results of the exercise test, into two groups: placebo responders and place-bo-non-responders. The anti-anginal effect of beta-blocking agents has been clearly demonstrated only in the placebo-non-responders group. No statistically significant effect of beta-blocking agents was observed in the placebo-responders group. This result shows that it is necessary, in double blind trials, at first to separate placebo-responders from placebo-non responders. Otherwise the correct evaluation of a drug can be modified by the placebo-responders group. |
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Authors:
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G Folli; M Radice; A Beltrami; S Potenza; G Mariotti |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Acta cardiologica Volume: 33 ISSN: 0001-5385 ISO Abbreviation: Acta Cardiol Publication Date: 1978 |
Date Detail:
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Created Date: 1978-12-20 Completed Date: 1978-12-20 Revised Date: 2009-06-11 |
Medline Journal Info:
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Nlm Unique ID: 0370570 Medline TA: Acta Cardiol Country: BELGIUM |
Other Details:
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Languages: eng Pagination: 231-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Angina Pectoris / drug therapy*, physiopathology Double-Blind Method Drug Evaluation Exercise Test Female Humans Male Middle Aged Placebos / therapeutic use* Practolol / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Placebos; 6673-35-4/Practolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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