Document Detail

Placebo effect in the treatment of angina pectoris.
MedLine Citation:
PMID:  309264     Owner:  NLM     Status:  MEDLINE    
The interference of placebo effect in the treatment of angina pectoris has been studied in a group of patients with stable angina pectoris, selected on the basis of normal electrocardiogram at rest and a pathologic ergometric electrocardiographic test. It was found that the patients could be divided, according to the results of the exercise test, into two groups: placebo responders and place-bo-non-responders. The anti-anginal effect of beta-blocking agents has been clearly demonstrated only in the placebo-non-responders group. No statistically significant effect of beta-blocking agents was observed in the placebo-responders group. This result shows that it is necessary, in double blind trials, at first to separate placebo-responders from placebo-non responders. Otherwise the correct evaluation of a drug can be modified by the placebo-responders group.
G Folli; M Radice; A Beltrami; S Potenza; G Mariotti
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta cardiologica     Volume:  33     ISSN:  0001-5385     ISO Abbreviation:  Acta Cardiol     Publication Date:  1978  
Date Detail:
Created Date:  1978-12-20     Completed Date:  1978-12-20     Revised Date:  2009-06-11    
Medline Journal Info:
Nlm Unique ID:  0370570     Medline TA:  Acta Cardiol     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  231-9     Citation Subset:  IM    
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MeSH Terms
Angina Pectoris / drug therapy*,  physiopathology
Double-Blind Method
Drug Evaluation
Exercise Test
Middle Aged
Placebos / therapeutic use*
Practolol / therapeutic use*
Reg. No./Substance:
0/Placebos; 6673-35-4/Practolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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