Document Detail


Place cells, navigational accuracy, and the human hippocampus.
MedLine Citation:
PMID:  9770226     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hippocampal formation in both rats and humans is involved in spatial navigation. In the rat, cells coding for places, directions, and speed of movement have been recorded from the hippocampus proper and/or the neighbouring subicular complex. Place fields of a group of the hippocampal pyramidal cells cover the surface of an environment but do not appear to do so in any systematic fashion. That is, there is no topographical relation between the anatomical location of the cells within the hippocampus and the place fields of these cells in an environment. Recent work shows that place cells are responding to the summation of two or more Gaussian curves, each of which is fixed at a given distance to two or more walls in the environment. The walls themselves are probably identified by their allocentric direction relative to the rat and this information may be provided by the head direction cells. The right human hippocampus retains its role in spatial mapping as demonstrated by its activation during accurate navigation in imagined and virtual reality environments. In addition, it may have taken on wider memory functions, perhaps by the incorporation of a linear time tag which allows for the storage of the times of visits to particular locations. This extended system would serve as the basis for a spatio-temporal event or episodic memory system.
Authors:
J O'Keefe; N Burgess; J G Donnett; K J Jeffery; E A Maguire
Related Documents :
21945156 - Endocardial cell epithelial-mesenchymal transformation requires type iii tgfβ receptor...
21946866 - Natural killer t cells in lipoprotein metabolism and atherosclerosis.
21704596 - A lipo-peg-pei complex for encapsulating curcumin that enhances its antitumor effects o...
22213296 - Inhibition of cyclin d1 by shrna is associated with enhanced sensitivity to conventiona...
2170656 - Outward-rectifying chloride channels in cultured adult and fetal human nasal epithelial...
10368806 - P53-independent apoptosis induced by genistein in lung cancer cells.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Philosophical transactions of the Royal Society of London. Series B, Biological sciences     Volume:  353     ISSN:  0962-8436     ISO Abbreviation:  Philos. Trans. R. Soc. Lond., B, Biol. Sci.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-12-23     Completed Date:  1998-12-23     Revised Date:  2010-08-25    
Medline Journal Info:
Nlm Unique ID:  7503623     Medline TA:  Philos Trans R Soc Lond B Biol Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1333-40     Citation Subset:  IM    
Affiliation:
Department of Anatomy and Developmental Biology, University College London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Brain Mapping
Hippocampus / cytology,  physiology*
Humans
Locomotion / physiology
Movement / physiology*
Neurons / physiology*
Rats
Spatial Behavior / physiology
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cross-modal links in spatial attention.
Next Document:  Neural representation of objects in space: a dual coding account.