| Pivotal role of the kidney in hypertension. | |
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MedLine Citation:
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PMID: 20610969 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The kidneys play a pivotal role in causing some forms of hypertension and probably a permissive role in most, if not all, forms of hypertension. This concept of the critical role of the kidneys has been postulated for many years but has been solidified by the molecular unraveling of several monogenic forms of hypertension such as Liddle's syndrome, apparent mineralocorticoid excess and glucocorticoid-remedial aldosteronism. These and other hypertensive disorders cause sodium retention through excess Na reabsorption in the distal nephron. Some disorders of salt wasting and relative hypotension such as Bartter's syndrome, Gitelman's syndrome and pseudohypoaldosteronism also localize to Na transport abnormalities in the distal nephron. Hypertensive in the general population may also result from subtle abnormalities in sodium balance resulting from alterations in the distal nephron. |
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Authors:
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L Lee Hamm; Kathleen S Hering-Smith |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: The American journal of the medical sciences Volume: 340 ISSN: 1538-2990 ISO Abbreviation: Am. J. Med. Sci. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2010-08-05 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 0370506 Medline TA: Am J Med Sci Country: United States |
Other Details:
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Languages: eng Pagination: 30-2 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA. lhamm@tulane.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Genetic Predisposition to Disease Genetic Variation Humans Hypertension / etiology*, genetics Kidney / physiology Kidney Diseases / complications*, genetics, physiopathology Sodium / metabolism Water-Electrolyte Imbalance |
| Grant Support | |
ID/Acronym/Agency:
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P20 RR017659-09/RR/NCRR NIH HHS; P20RR017659/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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7440-23-5/Sodium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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