Document Detail

Pivotal role of Twist in skeletal biology and pathology.
MedLine Citation:
PMID:  20696219     Owner:  NLM     Status:  MEDLINE    
Basic Helix-loop-Helix (bHLH) factors play important roles in development and disease. Recent functional and genetic analyses revealed that the bHLH factor Twist1 is a critical modulator of mesenchymal cell fate during skeletal development. Specifically, studies in mice and humans showed that Twist1 controls mesenchymal stem cell differentiation into chondrocytes, osteoblasts or adipocytes via direct and indirect mechanisms. In a physiological context, Twist1 targets several molecular mechanisms to induce positive or negative effects on osteoblastic cell growth, differentiation and survival. In a pathological context, Twist1 loss-of-function mutations induce premature cranial suture fusion (craniosynostosis) in the Saethre-Chotzen syndrome. In this syndrome, expansion of cranial osteogenesis at the suture level results from alterations in the balance between osteoprogenitor cell proliferation, differentiation and apoptosis. These studies provide mechanisms by which Twist1 plays a pivotal role in skeletal cell fate in normal and pathologic conditions, which may offer therapeutic perspectives in conditions where mesenchymal cell behaviour is compromised.
Hichem Miraoui; Pierre J Marie
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-08-07
Journal Detail:
Title:  Gene     Volume:  468     ISSN:  1879-0038     ISO Abbreviation:  Gene     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-09-27     Completed Date:  2010-10-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7706761     Medline TA:  Gene     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Laboratory of Osteoblast Biology and Pathology, INSERM, U606, Paris, F-75475, France.
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MeSH Terms
Cell Differentiation
Craniosynostoses / pathology
Muscle, Skeletal / metabolism*,  pathology*
Osteoblasts / cytology,  metabolism
Twist Transcription Factor / metabolism*
Reg. No./Substance:
0/Twist Transcription Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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