Document Detail

Pivalic acid-induced carnitine deficiency and physical exercise in humans.
MedLine Citation:
PMID:  8969283     Owner:  NLM     Status:  MEDLINE    
To study the effect of carnitine depletion on physical working capacity, healthy subjects were administered pivaloyl-conjugated antibiotics for 54 days. The mean carnitine concentration in serum decreased from 35.0 to 3.5 mmicromol/L, and in muscle from 10 to 4.3 micromol/g noncollagen protein (NCP). Exercise tests were performed before and after 54 days' administration of the drug. At submaximal exercise, there was a slight increase in the concentration of 3-hydroxybutyrate in serum, presumably caused by decreased fatty acid oxidation in the liver. There was also a decreased consumption of muscle glycogen, indicating decreased glycolysis in the skeletal muscle. The muscle presumably had enough energy available, since there was no significant decrease in the concentration of adenosine triphosphate (ATP) and creatine phosphate during exercise. The work at maximal oxygen uptake (VO2max) and the maximal heart rate were reduced. Since VO2max is considered dependent on heart function, carnitine depletion seemed to affect cardiac function.
K Abrahamsson; B O Eriksson; E Holme; U Jodal; A Jönsson; S Lindstedt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  45     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-01-22     Completed Date:  1997-01-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1501-7     Citation Subset:  IM    
Department of Pediatrics, Gothenburg University, Sweden.
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MeSH Terms
Amdinocillin Pivoxil / adverse effects*,  chemistry
Blood Glucose / metabolism
Carnitine / deficiency*
Fatty Acids, Nonesterified / blood
Glycogen / blood
Middle Aged
Pentanoic Acids / adverse effects
Pivampicillin / adverse effects*,  chemistry
Triglycerides / blood
Reg. No./Substance:
0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Pentanoic Acids; 0/Triglycerides; 32886-97-8/Amdinocillin Pivoxil; 33817-20-8/Pivampicillin; 541-15-1/Carnitine; 75-98-9/pivalic acid; 9005-79-2/Glycogen

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