| Pityriasis rosea (Gibert): abnormal distribution pattern of antigen presenting cells in situ. | |
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MedLine Citation:
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PMID: 2408415 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pityriasis rosea is a skin disease which is obscure in its etiology and pathogenesis. We studied its immunopathology by immunophenotyping the inflammatory cells in situ using monoclonal antibodies that define leukocyte subsets. Findings as to T-cells and their major subsets did not reveal disease-specific data. Monocytes stained only rarely. Neither natural killer cells, B-cells nor plasma cells were ever found. An unexpected finding was the presence within the infiltrates and rarely within the epidermis of cells having the immunophenotype of interdigitating cells (RFD1+). Intense and dendritic staining with anti-T6 and anti-HLA-DR indicated Langerhans cells to be present in the dermal infiltrates, in between these infiltrates in the papillary dermis, and focally within the parakeratotic horny layer. This Langerhans' cell pattern provides evidence for dermal Langerhans cell compartmentalization and transepidermal Langerhans' cell elimination. Such a distribution indicates a change in Langerhans' cell migration processes in pityriasis rosea pathogenesis. |
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Authors:
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J D Bos; P M Huisman; S R Krieg; W R Faber |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta dermato-venereologica Volume: 65 ISSN: 0001-5555 ISO Abbreviation: Acta Derm. Venereol. Publication Date: 1985 |
Date Detail:
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Created Date: 1985-07-02 Completed Date: 1985-07-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370310 Medline TA: Acta Derm Venereol Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 132-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antibodies, Monoclonal / immunology Antigens / analysis* Cell Movement Female Humans Immunoenzyme Techniques Immunologic Techniques Langerhans Cells / cytology, immunology, pathology Leukocytes / classification Male Pityriasis / immunology*, pathology T-Lymphocytes / classification |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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