Document Detail

Pityriasis rosea-like drug eruption due to nortriptyline in a patient with vulvodynia.
MedLine Citation:
PMID:  23343697     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Nortriptyline and other tricyclic antidepressants are widely used in the treatment of depression. They are also used in chronic pain syndromes such as vulvodynia. We report a case of pityriasis rosea (PR)-like eruption in a young woman who was treated with oral nortriptyline for vulvodynia.
CASE REPORT: The patient presented with photosensitivity and erythematous, well-defined, oval papules and patches, with fine collarettes of scale on the dorsal hands, upper arms, and trunk. She showed a complete resolution of her rash with discontinuation of nortriptyline, thereby supporting the diagnosis of a drug-induced reaction.
COMMENT: Pityriasis rosea-like drug eruptions have been associated with numerous medications, including angiotensin-converting enzyme inhibitors, antirheumatic drugs, lithium, and, more recently, biologics such as imatinib, adalimumab, and etanercept. A literature review did not reveal an association between PR-like drug eruptions and tricyclic antidepressants such as nortriptyline. We report a case of PR-like drug reaction to nortriptyline for clinical interest.
Haider K Bangash; Tunisia Finch; Vesna Petronic-Rosic; Aisha Sethi; Emily Abramsohn; Stacy Tessler Lindau
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of lower genital tract disease     Volume:  17     ISSN:  1526-0976     ISO Abbreviation:  J Low Genit Tract Dis     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-25     Completed Date:  2013-09-02     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  9704963     Medline TA:  J Low Genit Tract Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  226-9     Citation Subset:  IM    
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MeSH Terms
Administration, Oral
Antidepressive Agents / administration & dosage,  adverse effects*
Drug Eruptions / pathology
Nortriptyline / administration & dosage,  adverse effects*
Pityriasis Rosea / chemically induced*,  pathology
Vulvodynia / drug therapy*
Young Adult
Grant Support
1K23AG032870-01A1/AG/NIA NIH HHS; K23 AG032870/AG/NIA NIH HHS
Reg. No./Substance:
0/Antidepressive Agents; BL03SY4LXB/Nortriptyline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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