Document Detail

Pitx2 regulates gonad morphogenesis.
MedLine Citation:
PMID:  18678914     Owner:  NLM     Status:  MEDLINE    
Organ shape and size, and, ultimately, organ function, relate in part to the cell and tissue spatial arrangement that takes place during embryonic development. Despite great advances in the genetic regulatory networks responsible for tissue and organ development, it is not yet clearly understood how specific gene functions are linked to the specific morphogenetic processes underlying the internal organ asymmetries found in vertebrate animals. During female chick embryogenesis, and in contrast to males where both testes develop symmetrically, asymmetrical gonad morphogenesis results in only one functional ovary. The disposition of paired organs along the left-right body axis has been shown to be regulated by the activity of the homeobox containing gene pitx2. We have found that pitx2 regulates cell adhesion, affinity, and cell recognition events in the developing gonad primordium epithelia. This in turn not only allows for proper somatic development of the gonad cortex but also permits the proliferation and differentiation of primordial germ cells. We illustrate how Pitx2 activity directs asymmetrical gonad morphogenesis by controlling mitotic spindle orientation of the developing gonad cortex and how, by modulating cyclinD1 expression during asymmetric ovarian development, Pitx2 appears to control gonad organ size. All together our observations indicate that the effects elicited by Pitx2 during the development of the female chick ovary are critical for cell topology, growth, fate, and ultimately organ morphogenesis and function.
Joaquín Rodríguez-León; Concepción Rodríguez Esteban; Mercè Martí; Belén Santiago-Josefat; Ilir Dubova; Xavier Rubiralta; Juan Carlos Izpisúa Belmonte
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-08-04
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  105     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-13     Completed Date:  2008-09-16     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  11242-7     Citation Subset:  IM    
Center of Regenerative Medicine in Barcelona, Doctor Aiguader 88, 08003 Barcelona, Spain.
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MeSH Terms
Cell Adhesion / physiology
Cell Differentiation / physiology*
Cell Proliferation
Chick Embryo
Chickens / physiology*
Cyclin D1 / metabolism
Epithelium / embryology
Gene Expression Regulation, Developmental / physiology
Germ Cells / cytology,  physiology*
Homeodomain Proteins
Mitotic Spindle Apparatus / metabolism
Organ Size
Ovary / cytology,  embryology*
Testis / cytology,  embryology
Transcription Factors
Reg. No./Substance:
0/Homeodomain Proteins; 0/Transcription Factors; 136601-57-5/Cyclin D1; 184787-43-7/homeobox protein PITX2

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