| Pituitary volume in unaffected relatives of patients with schizophrenia and bipolar disorder. | |
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MedLine Citation:
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PMID: 18640787 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Hypothalamic-pituitary-adrenal (HPA) axis hyperactivity has been demonstrated in both schizophrenia and bipolar disorder, but the mechanisms underlying this abnormality are still unclear. Enlarged pituitary volume has been recently reported in patients with first episode psychosis and been interpreted as a consequence of an increased activation of the HPA axis. The aim of this study was to assess the contribution of familial liability to pituitary volume in schizophrenia and bipolar disorder. Pituitary volume may be an indirect measure of HPA axis activity. METHODS: MRI brain scans and measurements of pituitary volumes were obtained for 183 subjects: 26 patients with established schizophrenia or schizoaffective disorder, 44 of their unaffected first-degree relatives (22 familial schizophrenia, 22 non-familial schizophrenia), 29 patients with established bipolar disorder, 38 of their unaffected first-degree relatives, and 46 healthy comparison subjects. RESULTS: We found a significantly larger pituitary volume (effect size=0.7) in unaffected relatives of patients with schizophrenia compared with controls (p=0.002); the pituitary was even larger in relatives of patients with familial schizophrenia (effect size=0.8, p=0.005). We did not find a significant difference in pituitary volume when comparing the relatives of bipolar patients with controls. Among patients, those with schizophrenia who were receiving prolactin-elevating antipsychotics had an increased pituitary volume compared with controls (effect size=1.0, p=0.006). CONCLUSIONS: These results suggest that the larger pituitary volume previously reported in first episode schizophrenia could be partly due to a genetic susceptibility to over-activate the HPA axis. |
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Authors:
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Valeria Mondelli; Paola Dazzan; Andrea Gabilondo; Kalliopi Tournikioti; Muriel Walshe; Nicolette Marshall; Katja K Schulze; Robin M Murray; Colm McDonald; Carmine M Pariante |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-07-21 |
Journal Detail:
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Title: Psychoneuroendocrinology Volume: 33 ISSN: 0306-4530 ISO Abbreviation: Psychoneuroendocrinology Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-04 Completed Date: 2008-11-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7612148 Medline TA: Psychoneuroendocrinology Country: England |
Other Details:
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Languages: eng Pagination: 1004-12 Citation Subset: IM |
Affiliation:
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Division of Psychological Medicine, Institute of Psychiatry, King's College London, London, UK. valeria.mondelli@iop.kcl.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Bipolar Disorder / pathology* Brain / pathology Case-Control Studies Family* Female Humans Male Middle Aged Organ Size Pituitary Gland / pathology* Schizophrenia / pathology* |
| Grant Support | |
ID/Acronym/Agency:
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//Medical Research Council |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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