Document Detail


Pituitary and testicular function in spontaneously hypertensive rats.
MedLine Citation:
PMID:  6302057     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Levels of plasma gonadotropins, prolactin (PRL), and testosterone, and the testicular concentration, total content, and affinity of hCG binding sites were measured in male spontaneously hypertensive rats (SHR) and in genetically matched normotensive (WKY) rats. Hypertensive rats had higher plasma PRL and FSH levels and lower plasma testosterone levels. The affinity of testicular hCG binding sites was similar in SHR and WKY rats, but SHR had considerably lower concentration and total content of hCG-binding sites than did WKY animals. The comparison of these findings with those obtained previously with pituitary-grafted rats and with tumor-bearing rats indicates that the endocrine effects of hyperprolactinemia may vary depending on the rate and magnitude of the increase in peripheral PRL levels. Species differences in the response to hyperprolactinemia and differences between SHR and other rat strains suggest that hormonal responses to PRL elevation depend also on the genetic characteristics of the animal.
Authors:
A Amador; R W Steger; A Bartke; A Johns; R H Hayashi; M H Stallings
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of andrology     Volume:  4     ISSN:  0196-3635     ISO Abbreviation:  J. Androl.     Publication Date:    1983 Jan-Feb
Date Detail:
Created Date:  1983-06-10     Completed Date:  1983-06-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8106453     Medline TA:  J Androl     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  67-70     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Follicle Stimulating Hormone / blood
Gonadotropins, Pituitary / blood*
Hypertension / blood,  metabolism*
Luteinizing Hormone / blood
Male
Prolactin / blood
Rats
Receptors, Cell Surface / metabolism*
Receptors, LH
Testis / metabolism*
Testosterone / blood
Grant Support
ID/Acronym/Agency:
HD-12642/HD/NICHD NIH HHS; HD-12671/HD/NICHD NIH HHS; RR-05654/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Gonadotropins, Pituitary; 0/Receptors, Cell Surface; 0/Receptors, LH; 58-22-0/Testosterone; 9002-62-4/Prolactin; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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