Document Detail


Pituitary stem cells: candidates and implications.
MedLine Citation:
PMID:  23423660     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The pituitary is the master endocrine gland of the body. It undergoes many changes after birth, and these changes may be mediated by the differentiation of pituitary stem cells. Stem cells in any tissue source must display (1) pluripotent capacity, (2) capacity for indefinite self-renewal, and (3) a lack of specialization. Unlike neural stem cells identified in the hippocampus and subventricular zone, pituitary stem cells are not associated with one specific cell type. There are many major candidates that are thought to be potential pituitary stem cell sources. This article reviews the evidence for each of the major cell types and discuss the implications of identifying a definitive pituitary stem cell type.
Authors:
Farshad Nassiri; Michael Cusimano; Jeff A Zuccato; Safraz Mohammed; Fabio Rotondo; Eva Horvath; Luis V Syro; Kalman Kovacs; Ricardo V Lloyd
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-20
Journal Detail:
Title:  Pituitary     Volume:  -     ISSN:  1573-7403     ISO Abbreviation:  Pituitary     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9814578     Medline TA:  Pituitary     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Division of Neurosurgery, Department of Surgery, University of Toronto, 30 Bond Street, Toronto, ON, M5B 1W8, Canada, farshad.nassiri@mail.utoronto.ca.
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