Document Detail

Pituitary stalk duplication in association with moya moya disease and bilateral morning glory disc anomaly - broadening the clinical spectrum of midline defects.
MedLine Citation:
PMID:  18350354     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Duplication of the pituitary stalk, morning glory disc anomaly and moya moya are rare malformations. The combination of these findings may be syndromic and may have an underlying genetic etiology. METHODS: Case report and review of the literature of neurological, ophthalmological, and neuroradiological findings including ophthalmic examination, MRI and MRA. CASE REPORT: A 2 year-old girl presented with reduced visual acuity and roving eye movements since birth. Ophthalmological workup revealed bilateral morning glory disc anomaly. MRI showed duplication of the pituitary stalk and caudal displacement of the floor of the third ventricle. MRA showed narrowing of the supraclinoid internal carotid arteries with focal narrowing of the proximal middle cerebral arteries consistent with early moya moya disease. CONCLUSIONS: Review of the literature of pituitary gland duplication and of the combination of morning glory disc anomaly and moya moya disease revealed only one previously reported case. However, the spectrum of this possibly syndromic presentation may be much broader and include various types of anterior midline defects and may have a common underlying genetic cause.
T Loddenkemper; N R Friedman; P M Ruggieri; A Marcotty; J Sears; E I Traboulsi
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-03-20
Journal Detail:
Title:  Journal of neurology     Volume:  255     ISSN:  0340-5354     ISO Abbreviation:  J. Neurol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-08-20     Completed Date:  2008-10-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  885-90     Citation Subset:  IM    
Dept. of Neurology, The Cleveland Clinic Foundation, 9500 Euclid Ave, S-71, Cleveland, OH 44195, USA.
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MeSH Terms
Carotid Artery, Internal / pathology,  physiopathology
Cerebral Arteries / pathology*,  physiopathology
Child, Preschool
Disease Progression
Magnetic Resonance Angiography
Magnetic Resonance Imaging
Middle Cerebral Artery / pathology,  physiopathology
Moyamoya Disease / complications*,  physiopathology
Nervous System Malformations / complications*,  physiopathology
Optic Disk / abnormalities*
Pituitary Gland / abnormalities*
Retina / abnormalities*
Retinal Artery / abnormalities
Third Ventricle / abnormalities

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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