Document Detail

Pituitary gland growth during normal pregnancy: an in vivo study using magnetic resonance imaging.
MedLine Citation:
PMID:  3400697     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Autopsy studies have shown that pregnancy results in physiologic pituitary enlargement. We used magnetic resonance imaging (MRI) to corroborate those findings in vivo. PATIENTS AND METHODS: Based on gestational age, 32 normal primigravid patients were divided into three groups: Group I (n = 10), less than 12 gestational weeks; Group II (n = 11), 13 to 26 gestational weeks; and Group III (n = 11), 27 gestational weeks or more. The pituitary dimensions and volumes in these groups were compared with those in 20 healthy nulliparous women (control group). RESULTS: MRI measurements showed a significant increase in pituitary volume in Groups I, II, and III when compared with the control group (p less than 0.001). Furthermore, there was an increase in pituitary volume between Groups I and II and between Groups II and III, although the former was not statistically significant (p greater than 0.05). At the end of pregnancy, the hypophysis had increased 2.6 mm in vertical, anteroposterior, and transversal dimensions, with an overall increase of 136 percent when compared with that of the control group. CONCLUSION: Baseline measurements of the normal enlargement of the pituitary gland that occurs during pregnancy could prove useful when evaluating pregnant patients with suspected pituitary tumors or lymphocytic hypophysitis.
J G Gonzalez; G Elizondo; D Saldivar; H Nanez; L E Todd; J Z Villarreal
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of medicine     Volume:  85     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-09-02     Completed Date:  1988-09-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  217-20     Citation Subset:  AIM; IM    
Department of Internal Medicine, University Hospital, Monterrey, Mexico.
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MeSH Terms
Magnetic Resonance Imaging*
Pituitary Gland / anatomy & histology*,  growth & development
Pregnancy / physiology*

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