| Pituitary carcinoma recurrent to the lumbar intradural extramedullary space: case report. | |
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MedLine Citation:
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PMID: 22333938 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Pituitary tumors are rare, and pituitary carcinomas are rarer still. Prognosis is poor, with less than 50% of patients surviving past 1 year after diagnosis. In this case of spinal metastasis from an adrenocorticotropic hormone-secreting pituitary carcinoma, the intradural extramedullary metastases recurred in the same lumbar area 6 years apart. FINDINGS: Fourteen years prior to presentation in our clinic, a 48-year-old woman was diagnosed with pituitary adenoma which was treated with resection followed by radiation. Eight years later, an intradural extramedullary spinal drop metastasis at L2-L3 was again treated with resection and radiation. Three years later, magnetic resonance imaging (MRI) revealed a mass encasing the right carotid artery, which was treated for 1 year with chemotherapy using temozolomide (Temodar). Three years later, MRI showed intradural extramedullary metastases at the L3-L4 intervertebral disc space and behind the L3 vertebral body; treatment was again resection followed by radiation. Back pain and weakness resolved after surgery and her neurological examination returned to baseline. There was no evidence of recurrence 1 year after surgery. CONCLUSION/CLINICAL RELEVANCE: In this unusual case, this pituitary carcinoma metastasized twice in 6 years to virtually the same intradural extramedullary lumbar region. Surgical resection of these masses aided in relieving neurological symptoms and prolonging life. |
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Authors:
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Paul M Arnold; Denesh Ratnasingam; Maura F O'Neil; Philip L Johnson |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2012-02-08 |
Journal Detail:
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Title: The journal of spinal cord medicine Volume: 35 ISSN: 1079-0268 ISO Abbreviation: J Spinal Cord Med Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-04-24 Completed Date: 2012-06-21 Revised Date: 2013-04-15 |
Medline Journal Info:
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Nlm Unique ID: 9504452 Medline TA: J Spinal Cord Med Country: England |
Other Details:
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Languages: eng Pagination: 118-21 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, University of Kansas Medical Center, Kansas City, KS 66160, USA. parnold@kumc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma
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pathology* Female Humans Lumbosacral Region Magnetic Resonance Imaging Middle Aged Pituitary Neoplasms / pathology* Spinal Cord Neoplasms / secondary* |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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