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PITUITARY AUTOIMMUNITY IS ASSOCIATED WITH HYPOPITUITARISM IN PATIENTS WITH PRIMARY EMPTY SELLA.
MedLine Citation:
PMID:  21623153     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective: some evidences suggest that late stage autoimmune hypophysitis (AH) may result in empty sella (ES). Aim of the study was to assess the prevalence of serum pituitary antibodies (PitAbs) and their correlation with pituitary function in patients with ES. Design: in this case-control study 85 patients with primary ES, 16 patients with ES secondary to head trauma, 214 healthy controls, and 16 AH were enrolled in a tertiary referral center. Methods: PitAbs were assessed in all cases and controls. Endocrine function was assessed by basal hormone measurement and dynamic testing in all ES cases. Results: PitAbs prevalence was higher in primary ES (6%) than in healthy subjects (0.5% p=0.003) and lower than in AH patients (50%, p<0.0001). PitAbs were not found in patients with secondary ES. Hypopituitarism was found in 49% of primary ES and in 62% of secondary ES (p=0.34). A positive correlation between the presence of PitAbs and hypopituitarism was found in primary ES (p=0.02). Conclusions: the significant association between pituitary autoimmunity and hypopituitarism suggests that ES, in selected cases, could be the final result of AH.
Authors:
Isabella Lupi; Luca Manetti; Valentina Raffaelli; Lucia Grasso; Chiara Sardella; Mirco Cosottini; Aldo Iannelli; Maurizio Gasperi; Fausto Bogazzi; Patrizio Caturegli; Enio Martino
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-27
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  -     ISSN:  1720-8386     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Endocrinology and Metabolism University of Pisa (I.L., L.M., V.R., L.G., C.S., F.B., E.M.), 56124 Pisa, Italy. Department of Neuroscience (M.C., A.I.), University of Pisa, 56100 Pisa, Italy. Department of Health Sciences, Chair of Endocrinology, University of Molise, Campobasso, Italy (M.G.) Department of Pathology and Feinstone Department of Molecular Microbiology and Immunology (P.C.) The Johns Hopkins University, School of Medicine, 21205 Baltimore, MD USA.
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