Document Detail

Pituitary autoimmunity: 30 years later.
MedLine Citation:
PMID:  18774118     Owner:  NLM     Status:  MEDLINE    
Pituitary autoimmunity encompasses a spectrum of conditions ranging from histologically proven forms of lymphocytic hypophysitis to the presence of pituitary antibodies in apparently healthy subjects. Hypophysitis is a rare but increasingly recognized disorder that typically presents as a mass in the sella turcica. It mimics clinically and radiologically other non-functioning sellar masses, such as the more common pituitary adenoma. Hypophysitis shows a striking temporal association with pregnancy, and it has been recently described during immunotherapies that block CTLA-4. Several candidate pituitary autoantigens have been described in the last decade, although none has proven useful as a diagnostic tool. This review summarizes the advances made in the field since the publication of the first review on pituitary autoimmunity, and the challenges that await clarification.
Patrizio Caturegli; Isabella Lupi; Melissa Landek-Salgado; Hiroaki Kimura; Noel R Rose
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2008-05-08
Journal Detail:
Title:  Autoimmunity reviews     Volume:  7     ISSN:  1568-9972     ISO Abbreviation:  Autoimmun Rev     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-08     Completed Date:  2008-12-05     Revised Date:  2013-03-14    
Medline Journal Info:
Nlm Unique ID:  101128967     Medline TA:  Autoimmun Rev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  631-7     Citation Subset:  IM    
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States.
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MeSH Terms
Autoimmune Diseases / immunology*,  metabolism
Pituitary Diseases / immunology*
Pituitary Gland / immunology*
Pituitary Hormones / immunology
Grant Support
Reg. No./Substance:
0/Pituitary Hormones

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