Document Detail

Pituitary apoplexy due to mucormycosis infection in a patient with an ACTH producing pulmonary tumor.
MedLine Citation:
PMID:  17462904     Owner:  NLM     Status:  MEDLINE    
Rhinocerebral mucormycosis is an acute, fulminating form of invasive fungal sinusitis occurring principally in individuals who are immunologically or metabolically compromised. The incidence of pituitary apoplexy ranges from 6% to 17%, presenting as a capsule rupture in up to 1.7-2.0%. Isolated cases of mucormycosis are associated with solid tumors and Cushing's syndrome. A 42-year-old, diabetic woman, with Cushing's syndrome of 5 years duration presented with hemiplexy, hemiparesis and altered speech following a syncopal episode and fall. Brain CT scan showed a left temporal lobe infarction. The patient deteriorated rapidly and she died 4 days later. Autopsy findings included: plurihormonal pituitary adenoma with extension to the sphenoid bone and sellar erosion; many thick, septated, mucormycosis hyphae; and recent fronto-temporal brain infarction. Also, a solitary adrenal corticotropic hormone (ACTH)-producing neuroendocrine tumor, 3 cm in diameter, was found in the left lung. This patient illustrates the correlation between ACTH-producing ectopic pulmonary tumor, pituitary apoplexy and mucormycosis.
Citlaltépetl Salinas-Lara; Daniel Rembao-Bojórquez; Erick de la Cruz; Carlos Márquez; Lesly Portocarrero; Martha Lilia Tena-Suck
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-04-25
Journal Detail:
Title:  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia     Volume:  15     ISSN:  0967-5868     ISO Abbreviation:  J Clin Neurosci     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-10     Completed Date:  2008-05-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433352     Medline TA:  J Clin Neurosci     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  67-70     Citation Subset:  IM    
Department of Neuropathology, National Institute of Neurology and Neurosurgery, Mexico City, Mexico.
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MeSH Terms
Adrenocorticotropic Hormone / secretion*
Lung Neoplasms / complications,  pathology*,  secretion*
Mucormycosis / complications,  etiology*
Pituitary Apoplexy / etiology*
Pituitary Neoplasms / secondary*
Reg. No./Substance:
9002-60-2/Adrenocorticotropic Hormone

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