Document Detail

Pituitary-adrenocortical effects of methoxamine infusion on halothane anaesthetised ponies.
MedLine Citation:
PMID:  9839889     Owner:  NLM     Status:  MEDLINE    
This study investigated whether maintenance of normotension using a methoxamine infusion would prevent activation of the stress response during halothane anaesthesia in ponies. After acepromazine premedication, anaesthesia was induced with thiopentone in six ponies, and maintained for 120 minutes with halothane in oxygen and ventilation to normocapnia. Methoxamine (M, 0.013+/-0.005 mg kg(-1) min(-1)) or saline (C) was infused throughout anaesthesia. Sequential blood samples were taken for cortisol and ACTH assay. During anaesthesia normotension (mean arterial blood pressure 101-124 mm Hg) was maintained in M, whilst hypotension developed in C (nadir 71+/-12 mm Hg). Cardiac output decreased in both groups but to a greater extent in M. Systemic vascular resistance increased more in M (max 2015+/-650 dyne.s cm(-5)) than C (max 939+/-285 dyne.s cm(-5)). Plasma cortisol increased in both groups but more slowly in M. Plasma ACTH did not change in either group. Maintenance of normotension via increased systemic vascular resistance did not prevent, but may have attentuated, the adrenocortical response to anaesthesia. Reduced cardiac output and presumed compromise to tissue perfusion appear as important a stimulus as hypotension. The equine stress response to halothane anaesthesia is likely to be multifactorial.
D C Brodbelt; J Harris; P M Taylor
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Research in veterinary science     Volume:  65     ISSN:  0034-5288     ISO Abbreviation:  Res. Vet. Sci.     Publication Date:    1998 Sep-Oct
Date Detail:
Created Date:  1999-02-12     Completed Date:  1999-02-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0401300     Medline TA:  Res Vet Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  119-23     Citation Subset:  IM    
Department of Clinical Veterinary Medicine, University of Cambridge, UK.
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MeSH Terms
Adrenergic alpha-Agonists / administration & dosage,  pharmacology*
Adrenocorticotropic Hormone / blood,  secretion
Anesthesia, Inhalation*
Blood Pressure / drug effects
Carbon Dioxide / blood
Cardiac Output / drug effects
Creatine Kinase / blood
Heart Rate / drug effects
Hemodynamics / drug effects*
Hydrocortisone / blood
Infusions, Intravenous
Methoxamine / administration & dosage,  pharmacology*
Oxygen / blood
Partial Pressure
Pituitary-Adrenal System / drug effects,  physiology*
Respiration / drug effects
Vascular Resistance / drug effects
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 124-38-9/Carbon Dioxide; 151-67-7/Halothane; 390-28-3/Methoxamine; 50-23-7/Hydrocortisone; 7782-44-7/Oxygen; 9002-60-2/Adrenocorticotropic Hormone; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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