| Pituitary adenylate cyclase activating polypeptide (PACAP) redistributes the blood within the pancreas of anesthetized rats. | |
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MedLine Citation:
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PMID: 8837220 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the study was to evaluate the effects of pituitary adenylate cyclase activating polypeptide-38 (PACAP-38) on splanchnic blood flow in anesthetized rats. For this purpose, either PACAP-38 dissolved in saline or saline alone was injected intravenously 5 (10 nmol/kg body weight (bw) PACAP-38) and 30 min (5 or 10 nmol/kg) before measurements. The blood flow to the whole pancreas, islets, duodenum and colon was then measured with a microsphere technique. The higher dose of PACAP-38 slightly increased blood glucose concentrations at both 5 and 30 min after administration, whereas the lower had no effect. Both doses of PACAP-38 induced a transient initial decrease in mean arterial blood pressure. The lower dose of PACAP-38 decreased fractional islet blood flow 30 min after administration, but did not affect the other blood flows. The higher dose of the peptide (10 nmol/kg bw) caused an increase in whole pancreatic blood flow at both 5 and 30 min after administration, whereas islet blood flow was only increased at the former time. At both time points PACAP-38 redistributed the blood flow within the pancreas in favour of the exocrine pancreas. This resulted in a decreased fractional islet blood flow, i.e., the fraction of whole pancreatic blood flow diverted through the islets. At 5 min after PACAP-38 administration duodenal blood flow was decreased, whereas after 30 min no effects on duodenal or colonic blood flow were observed. Administration of a VIP antagonist intravenously (20 nmol/kg bw) decreased the PACAP-38-induced pancreatic blood flow increase and intrapancreatic redistribution. When only the VIP antagonist was given both pancreatic and islet blood decreased in concert. It is concluded that administration of PACAP-38 induces a blood flow increase in the pancreas, preferably in the exocrine parts of the gland, by actions mediated by PACAP-38 receptors shared with VIP. |
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Authors:
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P O Carlsson; C G Ostenson; S Efendic; U Langel; L Jansson |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Regulatory peptides Volume: 63 ISSN: 0167-0115 ISO Abbreviation: Regul. Pept. Publication Date: 1996 Jul |
Date Detail:
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Created Date: 1996-12-10 Completed Date: 1996-12-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8100479 Medline TA: Regul Pept Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 123-8 Citation Subset: IM |
Affiliation:
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Department of Medical Cell Biology, Uppsala University, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Blood Circulation / drug effects Blood Glucose / drug effects Blood Pressure / drug effects Body Weight / drug effects Male Molecular Sequence Data Neuropeptides / pharmacology* Pancreas / drug effects* Peptides / chemistry, pharmacology Pituitary Adenylate Cyclase-Activating Polypeptide Pituitary Gland / enzymology Rats Rats, Sprague-Dawley Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide Receptors, Pituitary Hormone / metabolism* Receptors, Vasoactive Intestinal Peptide / antagonists & inhibitors, metabolism Vasoactive Intestinal Peptide / pharmacology Vasodilator Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Adcyap1 protein, rat; 0/Blood Glucose; 0/Neuropeptides; 0/Peptides; 0/Pituitary Adenylate Cyclase-Activating Polypeptide; 0/Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; 0/Receptors, Pituitary Hormone; 0/Receptors, Vasoactive Intestinal Peptide; 0/Vasodilator Agents; 37221-79-7/Vasoactive Intestinal Peptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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