| Pituitary adenylate cyclase-activating polypeptide dilates cerebral arterioles of newborn pigs. | |
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MedLine Citation:
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PMID: 8390692 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The actions of the 38- and 27-amino acid forms of synthetic pituitary adenylate cyclase-activating polypeptide (PACAP-38 and PACAP-27) on cerebral arterioles were tested in anesthetized newborn pigs equipped with closed cranial windows. The diameter changes of pial arterioles to topical PACAP were measured and cortical periarachnoid cerebrospinal fluid samples were collected for measurement of cAMP. The 38- and 27-amino acid forms of PACAP produced similar dose-dependent vasodilations. The increases of pial arteriolar diameter produced by PACAP-38 were 6 +/- 1%, 15 +/- 2%, 23 +/- 3%, and 38 +/- 3%, and those produced by PACAP-27 were 6 +/- 1%, 15 +/- 2%, 27 +/- 5%, and 38 +/- 8% at 10((-9), 10(-8), 10(-7), and 10(-6) M, respectively. Arteriolar diameter began to increase 1-2 min and reached a maximum 6-8 min after topical application of PACAP. Vasoactive concentrations of PACAP-38 and PACAP-27 increased cerebrospinal fluid cAMP levels dose dependently. Thus, PACAP-38 and PACAP-27 appear to stimulate cerebral adenylate cyclase and are potent dilators of newborn pigs pial arterioles. |
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Authors:
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S Tong; H Parfenova; M Shibata; S Zuckerman; W M Armstead; C W Leffler |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) Volume: 203 ISSN: 0037-9727 ISO Abbreviation: Proc. Soc. Exp. Biol. Med. Publication Date: 1993 Jul |
Date Detail:
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Created Date: 1993-07-16 Completed Date: 1993-07-16 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7505892 Medline TA: Proc Soc Exp Biol Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 343-7 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biophysics, University of Tennessee, Memphis 38163. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Arterioles / drug effects, physiology Brain / blood supply* Cyclic AMP / cerebrospinal fluid Kinetics Neuropeptides / administration & dosage, pharmacology* Pia Mater / blood supply Pituitary Adenylate Cyclase-Activating Polypeptide Swine Vasodilation / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
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HL34059/HL/NHLBI NIH HHS; HL42851/HL/NHLBI NIH HHS; HL42875/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Neuropeptides; 0/Pituitary Adenylate Cyclase-Activating Polypeptide; 60-92-4/Cyclic AMP |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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