Document Detail

Pituitary adenylate cyclase activating polypeptide (PACAP) reduces food intake in mice.
MedLine Citation:
PMID:  1494495     Owner:  NLM     Status:  MEDLINE    
Pituitary adenylate cyclase activating peptide (PACAP) is a peptide that is present in the hypothalamus and other areas of the rat brain. This study demonstrates that PACAP reduces food intake after intracerebroventricular injection in food-deprived mice. Behavioral analysis suggests that this decrease in food intake is, in part, compensated for by an increase in other behaviors. Pituitary adenylate cyclase activating peptide also was demonstrated to antagonize increased food intake resulting from administration of neuropeptide Y. Thus, PACAP joins a growing list of neuropeptides involved in the central regulation of food intake.
J E Morley; M Horowitz; P M Morley; J F Flood
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Peptides     Volume:  13     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:    1992 Nov-Dec
Date Detail:
Created Date:  1993-03-09     Completed Date:  1993-03-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1133-5     Citation Subset:  IM    
Geriatric Research Education and Clinical Center (GRECC), VA Medical Center, St. Louis, MO 63125.
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MeSH Terms
Behavior, Animal / drug effects
Eating / drug effects*
Food Deprivation / physiology
Injections, Intraventricular
Neuropeptide Y / pharmacology
Neuropeptides / pharmacology*
Pituitary Adenylate Cyclase-Activating Polypeptide
Reg. No./Substance:
0/Adcyap1 protein, mouse; 0/Neuropeptide Y; 0/Neuropeptides; 0/Pituitary Adenylate Cyclase-Activating Polypeptide

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