| Pituitary adenylate cyclase-activating polypeptide induces secretion of growth hormone in cattle. | |
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MedLine Citation:
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PMID: 11707364 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pituitary adenylate cyclase-activating polypeptide (PACAP) is a hypothalamic neuropeptide that stimulates release of growth hormone (GH) from cultured bovine anterior pituitary gland cells, but the role of PACAP on the regulation of in vivo secretion of GH in cattle is not known. To test the hypothesis that PACAP induces secretion of GH in cattle, meal-fed Holstein steers were injected with incremental doses of PACAP (0, 0.1, 0.3, 1, 3, and 10 microg/kg BW) before feeding and concentrations of GH in serum were quantified. Compared with saline, injection of 3 and 10 microg PACAP/kg BW increased peak concentrations of GH in serum from 11.2 ng/ml to 23.7 and 21.8 ng/ml, respectively (P < 0.01). Peak concentrations of GH in serum were similar in steers injected with 3 or 10 microg PACAP/kg BW. Meal-fed Holstein steers were then injected with 3 microg/PACAP/kg BW either 1 hr before feeding or 1 hr after feeding to determine if PACAP-induced secretion of GH was suppressed after feeding. Feeding suppressed basal concentrations of GH in serum. Injection of PACAP before feeding induced greater peak concentrations of GH in serum (19.2 +/- 2.6 vs. 11.7 +/- 2.6 ng/ml) and area under the response curve (391 +/- 47 vs. 255 +/- 52 ng. ml(-1) min) than injection of PACAP after feeding, suggesting somatotropes become refractory to PACAP after feeding similar to that observed by us and others with growth hormone-releasing hormone (GHRH). We concluded that PACAP induces secretion of GH and could play a role in regulating endogenous secretion of GH in cattle, perhaps in concert with GHRH. |
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Authors:
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R P Radcliff; K J Lookingland; L T Chapin; H A Tucker |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Domestic animal endocrinology Volume: 21 ISSN: 0739-7240 ISO Abbreviation: Domest. Anim. Endocrinol. Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-11-14 Completed Date: 2002-01-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8505191 Medline TA: Domest Anim Endocrinol Country: United States |
Other Details:
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Languages: eng Pagination: 187-96 Citation Subset: IM |
Affiliation:
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Department of Animal Science, Michigan State University, East Lansing, MI 48824-1225, USA. RadcliffR@missourri.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Area Under Curve Cattle / physiology* Cross-Over Studies Dose-Response Relationship, Drug Gonadotropin-Releasing Hormone / pharmacology, physiology Growth Hormone / blood, secretion* Male Neuropeptides / pharmacology*, physiology Pituitary Adenylate Cyclase-Activating Polypeptide Random Allocation |
| Chemical | |
Reg. No./Substance:
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0/Neuropeptides; 0/Pituitary Adenylate Cyclase-Activating Polypeptide; 33515-09-2/Gonadotropin-Releasing Hormone; 9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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