Document Detail


Pituitary adenomas in the old-aged.
MedLine Citation:
PMID:  9519682     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
From 1986 to 1996, 187 patients with pituitary adenoma were diagnosed and received surgery at Kaohsiung Medical College Hospital. Of which, 29 patients older than 60 years were retrospectively studied. Their initial clinical symptoms, pathological findings, immunoperoxidase staining, electronic microscopic findings and hormone levels were retrospectively recorded. We found that the old patients more often suffered from the neurological deficit such as headache and visual problems rather than endocrine of the tumors cells are compared, and fewer cells and nuclei are found in the older group than that in the younger group. The secretary granules in functioning tumors especially prolactinomas in old-aged patients are larger than those in the young patients. The tumor cells in the old-aged patients have fewer subcellular organelles and secretary granules but have large secretary granules. It is concluded that: (1) transsphenoidal surgery is feasible and safe in this age group; (2) plurihormonal tumors occur more frequently in old-age than young patients; (3) clinically endocrine-inactive pituitary adenomas occur more often in old-aged; (4) pituitary adenomas in old-aged cause neurological deficit more frequently than endocrine disturbance.
Authors:
C Z Chang; C J Wang; S L Hwang; S L Howng
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Kaohsiung journal of medical sciences     Volume:  14     ISSN:  1607-551X     ISO Abbreviation:  Kaohsiung J. Med. Sci.     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-04-09     Completed Date:  1998-04-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100960562     Medline TA:  Kaohsiung J Med Sci     Country:  TAIWAN    
Other Details:
Languages:  eng     Pagination:  1-5     Citation Subset:  IM    
Affiliation:
Department of Surgery, Kaohsiung Medical College Hospital, Taiwan, Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Adenoma / secretion,  ultrastructure*
Adrenocorticotropic Hormone / secretion
Adult
Age Factors
Aged
Cytoplasmic Granules / ultrastructure
Female
Humans
Male
Pituitary Neoplasms / secretion,  ultrastructure*
Prolactin / blood
Chemical
Reg. No./Substance:
9002-60-2/Adrenocorticotropic Hormone; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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