Document Detail

Pituitary abnormalities in eating disorders: further evidence from MRI studies.
MedLine Citation:
PMID:  1862218     Owner:  NLM     Status:  MEDLINE    
1. The frequent occurrence of hypothalamo-pituitary dysfunction in patients with eating disorders as well as prior reports that nutritional and endocrine status influence pituitary morphology, led us to hypothesize that pituitary size and shape may be altered in patients with eating disorders. 2. Magnetic resonance imaging (MRI) does not use ionizing radiation and is currently one of the most feasible modalities available to study the pituitary gland in vivo. Using MRI, we have previously reported in a preliminary study that female patients with eating disorders had significantly smaller pituitary glands than controls. In addition MRI excluded any pituitary mass lesions. 3. In this report, we confirm our previous MRI findings and provide further evidence of pituitary abnormalities in an expanded sample of eating disorder patients. Preliminary data on pituitary volume estimates from MRI scans are provided for a subset of patients and controls.
P M Doraiswamy; K R Krishnan; O B Boyko; M M Husain; G S Figiel; V J Palese; P R Escalona; S A Shah; W M McDonald; W J Rockwell
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  15     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  1991  
Date Detail:
Created Date:  1991-08-30     Completed Date:  1991-08-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  351-6     Citation Subset:  IM    
Department of Psychiatry, Duke University Medical Center, Durham, NC.
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MeSH Terms
Anorexia / pathology
Bulimia / pathology
Eating Disorders / pathology*
Magnetic Resonance Imaging
Optic Chiasm / pathology
Pituitary Gland / abnormalities*,  pathology
Grant Support

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