| Pituitary insufficiency after infectious meningitis: a prospective study. | |
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MedLine Citation:
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PMID: 20427491 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Data from previous retrospective studies and case reports have suggested that infectious diseases of the central nervous system could cause pituitary deficiency. OBJECTIVE: The aim of this prospective study was to investigate pituitary function in patients admitted with infectious meningitis during the acute phase and after 12 months. DESIGN: Sixteen patients were studied. Basal pituitary function was assessed within 24 h of admission. Twelve of these patients underwent both basal and stimulated (insulin tolerance test) pituitary testing after 12 months. RESULTS: During the acute phase, five patients (31.25%) showed apparent pituitary hormone deficiencies: two patients with gonadotropic and three patients with somatotropic deficiency. The exact status of corticosteroid sufficiency could not be defined in four patients, because no dynamic test was performed in the acute phase. In addition, seven patients (44%) had probable low T(3) syndrome. At 12 months, five patients (31.25%), two with viral and three with bacterial meningitis, had at least one anterior pituitary hormone deficiency. Two patients had isolated corticotropic and one isolated somatotropic deficiency. Combined corticotropic and somatotropic deficiencies were detected in two patients. New-onset deficiencies accounted for four of those five patients, whereas one patient demonstrated persisting somatotropic deficiency. All cases of low T(3) syndrome resolved at 12 months. CONCLUSIONS: Isolated or combined pituitary deficiencies, which could present at the acute phase and/or occur at a later stage, can develop in a considerable proportion of patients after acute infectious meningitis. |
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Authors:
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Aristotelis Tsiakalos; Ioannis D Xynos; Nikolaos V Sipsas; Gregory Kaltsas |
Publication Detail:
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Type: Journal Article Date: 2010-04-28 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 95 ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2010-07-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 3277-81 Citation Subset: AIM; IM |
Affiliation:
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Pathophysiology Department, Athens University Medical School, Mikras Asias 75, 11527 Athens, Greece. atsiakalos@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Female Humans Hypopituitarism / diagnosis*, etiology* Male Meningitis, Bacterial / complications* Meningitis, Viral / complications* Middle Aged Prospective Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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