Document Detail


Pituitary Function in Patients with Hereditary Haemochromatosis.
MedLine Citation:
PMID:  23033214     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Haemochromatosis may impair the function of endocrine organs, amongst others the pituitary gland. It was the aim of this study to determine pituitary function in adult patients with genetically defined hereditary haemochromatosis in a prospective diagnostic study using a standardised stimulation test. Therefore, 22 patients (7 females, 15 males; age at diagnosis of haemochromatosis 48.1±7.9 years; age at study inclusion 50.7±7.7 years) with genetically defined hereditary haemochromatosis were investigated by a combined pituitary stimulation test (CRH, GHRH/arginine, GnRH, TRH). In 11 patients (50% of the study population; 2 females, 9 males), pituitary insufficiencies were detected [isolated corticotrophic insufficiency (peak cortisol < 181.25 μg/l/500 nmol/l) n=10 (2 females, 8 males); combined corticotrophic and borderline gonadotrophic insufficiency (basal testosterone 2.4-3.0 μg/l without basal LH-elevation) in 1 male]. Somatotrophic pituitary insufficiencies were not found. IFG-1 concentrations below -2 standard deviations in 7 patients (32%) may be attributed to impaired hepatic IGF-1 synthesis. Hypopituitarism, particularly corticotrophic insufficiency, seems to be prevalent in a considerable number of middle-aged patients with hereditary haemochromatosis. Despite normal somatotrophic function, low IGF-1 serum concentrations may be found in a subgroup of haemochromatosis patients.
Authors:
P M Uitz; S Hartleb; S Schaefer; N Al-Fakhri; P H Kann
Related Documents :
16887374 - Exploring the relationship between essential tremor and parkinson's disease.
20629164 - Parkinson's disease symptoms: the patient's perspective.
12411124 - Clinical course and cause of death in elderly patients with idiopathic parkinson's dise...
7824114 - Degeneration of substantia nigra in chronic parkinson's disease visualized by transcran...
19286604 - Periventricular white matter lucencies relate to low vitamin b12 levels in patients wit...
19376304 - Rationale and design of re-ly: randomized evaluation of long-term anticoagulant therapy...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-2
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme     Volume:  -     ISSN:  1439-4286     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Affiliation:
Division of Endocrinology & Diabetology, Faculty of Medicine and University Hospital, Philipp's University, Marburg, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  STARD4 knockdown in HepG2 cells disrupts cholesterol trafficking associated with the plasma membrane...
Next Document:  NMR of hyperpolarised probes.