| Pittsburgh compound-B and Alzheimer's disease biomarkers in CSF, plasma and urine: An exploratory study. | |
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MedLine Citation:
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PMID: 20332638 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The positron emission tomography (PET) radiotracer Pittsburgh Compound-B (PIB) is an in vivo ligand for measuring beta-amyloid (Abeta) load. Associations between PET PIB and cerebrospinal fluid (CSF) Abeta1-42 and apolipoprotein E epsilon4 (APOE epsilon4) have been observed in several studies, but the relations between PIB uptake and other biomarkers of Alzheimer's disease (AD) are less investigated. METHOD: PET PIB, PET 18Fluoro-2-deoxy-D-glucose and different AD biomarkers were measured twice in CSF, plasma and urine 12 months apart in 10 patients with a clinical diagnosis of mild to moderate AD. RESULTS: PIB retention was constant over 1 year, inversely related to low CSF Abeta1-42 (p = 0.01) and correlated positively to the numbers of the APOE epsilon4 allele (0, 1 or 2) (p = 0.02). There was a relation between mean PIB retention and CSF ApoE protein (r = -0.59, p = 0.07), and plasma cystatin C (r = -0.56, p = 0.09). CONCLUSION: PIB retention is strongly related to CSF Abeta1-42, and to the numbers of the APOE epsilon4 allele. |
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Authors:
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M Degerman Gunnarsson; M Lindau; A Wall; K Blennow; T Darreh-Shori; S Basu; A Nordberg; A Larsson; L Lannfelt; H Basun; L Kilander |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-20 |
Journal Detail:
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Title: Dementia and geriatric cognitive disorders Volume: 29 ISSN: 1421-9824 ISO Abbreviation: Dement Geriatr Cogn Disord Publication Date: 2010 |
Date Detail:
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Created Date: 2010-04-16 Completed Date: 2010-07-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9705200 Medline TA: Dement Geriatr Cogn Disord Country: Switzerland |
Other Details:
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Languages: eng Pagination: 204-12 Citation Subset: IM |
Copyright Information:
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2010 S. Karger AG, Basel. |
Affiliation:
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Department of Public Health/Geriatrics, Uppsala University, Sweden. malin.degerman.gunnarsson@akademiska.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Alzheimer Disease / metabolism*, radionuclide imaging Amyloid beta-Protein / blood, cerebrospinal fluid, urine Aniline Compounds / analysis*, metabolism Apolipoproteins E / genetics Biological Markers / blood, cerebrospinal fluid, urine Brain / radionuclide imaging Cognition / physiology Data Interpretation, Statistical Education Enzyme-Linked Immunosorbent Assay Female Glucose / metabolism Humans Male Middle Aged Neuropsychological Tests Positron-Emission Tomography Psychiatric Status Rating Scales Psychometrics Radiopharmaceuticals / diagnostic use Risk Factors Thiazoles / analysis*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; 0/Amyloid beta-Protein; 0/Aniline Compounds; 0/Apolipoproteins E; 0/Biological Markers; 0/Radiopharmaceuticals; 0/Thiazoles; 50-99-7/Glucose |
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