| Pitted red cell counts in sickle cell disease. Relationship to age, hemoglobin genotype, and splenic size. | |
| | |
MedLine Citation:
|
PMID: 3799933 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Splenic reticuloendothelial function, as determined by pitted red cell counts in 114 pediatric patients with sickle cell disease, was evaluated. Patients with homozygous sickle cell disease (HbSS) had a mean pit count of 11.8 +/- 7.0% and the count increased with age. Sickle cell hemoglobin C disease (HbSC) patients had a mean pit count of 4.9 +/- 9.1%, the count being unaffected by age. One patient with HbS-beta thalassemia had a count of 12%, while eight patients with HbS-beta + thalassemia had a mean count of 0.4 +/- 0.3%. There was one patient each with HbSS-alpha thalassemia, HbS-O Arab, and HbS-Lepore, and the pit counts were 4.9, 31.4, and 0.4%, respectively. In both HbSS and HbSC patients, the pit count was significantly lower in patients who had palpable spleens. The pit count may be used as a predictor of disease severity in the sickle cell disorders. |
| | |
Authors:
|
O J Fatunde; R B Scott |
Related Documents
:
|
7004533 - Concomitant administration of granulocyte transfusions and amphotericin b in neutropeni... 11293293 - Klebsiella pneumoniae meningitis in thalassemia major patients. 15472843 - Clinical characteristics of patients in peru with human t cell lymphotropic virus type ... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The American journal of pediatric hematology/oncology Volume: 8 ISSN: 0192-8562 ISO Abbreviation: Am J Pediatr Hematol Oncol Publication Date: 1986 |
Date Detail:
|
Created Date: 1987-02-18 Completed Date: 1987-02-18 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7908071 Medline TA: Am J Pediatr Hematol Oncol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 329-33 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Age Factors Anemia, Sickle Cell / blood*, pathology Child Child, Preschool Erythrocytes, Abnormal / pathology Hemoglobin SC Disease / blood, pathology Hemoglobins, Abnormal / physiology Humans Infant Spleen / pathology Thalassemia / blood |
| Grant Support | |
ID/Acronym/Agency:
|
HLB 15160/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Hemoglobins, Abnormal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Selection of replacement therapy for patients with severe factor VII deficiency.
Next Document: Thiopental kinetics in high-dose use