Document Detail

Pitted red cell counts in sickle cell disease. Relationship to age, hemoglobin genotype, and splenic size.
MedLine Citation:
PMID:  3799933     Owner:  NLM     Status:  MEDLINE    
Splenic reticuloendothelial function, as determined by pitted red cell counts in 114 pediatric patients with sickle cell disease, was evaluated. Patients with homozygous sickle cell disease (HbSS) had a mean pit count of 11.8 +/- 7.0% and the count increased with age. Sickle cell hemoglobin C disease (HbSC) patients had a mean pit count of 4.9 +/- 9.1%, the count being unaffected by age. One patient with HbS-beta thalassemia had a count of 12%, while eight patients with HbS-beta + thalassemia had a mean count of 0.4 +/- 0.3%. There was one patient each with HbSS-alpha thalassemia, HbS-O Arab, and HbS-Lepore, and the pit counts were 4.9, 31.4, and 0.4%, respectively. In both HbSS and HbSC patients, the pit count was significantly lower in patients who had palpable spleens. The pit count may be used as a predictor of disease severity in the sickle cell disorders.
O J Fatunde; R B Scott
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of pediatric hematology/oncology     Volume:  8     ISSN:  0192-8562     ISO Abbreviation:  Am J Pediatr Hematol Oncol     Publication Date:  1986  
Date Detail:
Created Date:  1987-02-18     Completed Date:  1987-02-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7908071     Medline TA:  Am J Pediatr Hematol Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  329-33     Citation Subset:  IM    
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MeSH Terms
Age Factors
Anemia, Sickle Cell / blood*,  pathology
Child, Preschool
Erythrocytes, Abnormal / pathology
Hemoglobin SC Disease / blood,  pathology
Hemoglobins, Abnormal / physiology
Spleen / pathology
Thalassemia / blood
Grant Support
Reg. No./Substance:
0/Hemoglobins, Abnormal

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