| Pitrakinra for asthma. | |
| | |
MedLine Citation:
|
PMID: 20923253 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
IMPORTANCE OF THE FIELD: In asthma IL-4 and IL-13 have been demonstrated to play major pathogenic roles and therefore their blockade would potentially represent a plausible therapeutic approach. AREAS COVERED IN THIS REVIEW: Pitrakinra is a dual IL-4/IL-13 inhibitor currently under development for asthma and the existing preclinical and clinical data are discussed. WHAT THE READER WILL GAIN: Inhaled pitrakinra demonstrated a good anti-inflammatory potential and a good safety profile on a short-term basis but its place in asthma therapy is still to be found. TAKE HOME MESSAGE: Specific anticytokine therapies might in the near future reshape asthma therapy. |
| | |
Authors:
|
Sabina A Antoniu; Ileana Cojocaru |
Related Documents
:
|
3936563 - Mediators and asthma. 20415863 - 99th dahlem conference on infection, inflammation and chronic inflammatory disorders: f... 11769963 - Cytokine deregulation in cancer. |
Publication Detail:
|
Type: Journal Article Date: 2010-10-05 |
Journal Detail:
|
Title: Expert opinion on biological therapy Volume: 10 ISSN: 1744-7682 ISO Abbreviation: Expert Opin Biol Ther Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-10-19 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101125414 Medline TA: Expert Opin Biol Ther Country: England |
Other Details:
|
Languages: eng Pagination: 1609-15 Citation Subset: IM |
Affiliation:
|
Department of Medicine II -Pulmonary Disease, Gr T Popa University of Medicine and Pharmacy Iaşi, Pulmonary Disease University Hospital, 30 Dr I Cihac Str, 700115 Iasi, Romania. sabina.antonela.antoniu@pneum.umfiasi.ro |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Thermodynamic descriptors, profiles and driving forces in membrane receptor-ligand interactions.
Next Document: Novel mesalamine-loaded beads in tablets for delayed release of drug to the colon.