Document Detail

Pitfalls in randomized surgical trials.
MedLine Citation:
PMID:  6987765     Owner:  NLM     Status:  MEDLINE    
Special problems may arise when the principles of the randomized trial are used to compare operative methods. In the trial design that is used at present, each surgeon performs the operatons to be compared in a random order. A prerequisite for a trial so designed to result in a fair comparison is that the participating surgeons are equally conversant with both techniques. If they are not, the design may imply systematic bias in favor of operations that are in wide use and bias in favor of technically simple procedures. An alternative to this design is given. Reports on trials should contain information about pretrial routine and level of training of participants.
W van der Linden
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Surgery     Volume:  87     ISSN:  0039-6060     ISO Abbreviation:  Surgery     Publication Date:  1980 Mar 
Date Detail:
Created Date:  1980-05-14     Completed Date:  1980-05-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0417347     Medline TA:  Surgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  258-62     Citation Subset:  AIM; E; IM    
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MeSH Terms
Clinical Trials as Topic
Random Allocation
Research Design / standards*
Surgical Procedures, Operative / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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