Document Detail

Pitfalls in the diagnosis of ectopic hamartomatous thymoma.
MedLine Citation:
PMID:  8971562     Owner:  NLM     Status:  MEDLINE    
We describe four cases of ectopic hamartomatous thymoma with unusual morphological features. In cases 1 and 2 we found a dysplastic glandular component which was often arranged in a cribriform pattern bridging several glandular spaces. In case 2 we found solid adenocarcinomatous areas with infiltrative edges. Case 3 showed widespread smooth muscle differentiation within the spindle epithelial cell component, the presence of multiple clear cell glands which contained a distinct myoepithelial layer and an overall picture which vaguely resembled a sclerosing adenosis of the breast. Case 4 contained frequent foci of multinucleated giant epithelial cells within the markedly cellular spindle cell component: it also showed multiple, hypocellular, myxoid areas containing eosinophilic cords and pearls of squamous cells, and resembled squamous cell carcinoma with a sarcomatoid spindle cell component. We could not find any evidence of a thymic origin or of thymic differentiation in our four cases or in any other reported cases of ectopic hamartomatous thymoma. We believe that ectopic hamartomatous thymomas manifest salivary gland differentiation.
M Michal; M Zámecník; M Gogora; P Mukensnabl; L Neubauer
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Histopathology     Volume:  29     ISSN:  0309-0167     ISO Abbreviation:  Histopathology     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-03-11     Completed Date:  1997-03-11     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7704136     Medline TA:  Histopathology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  549-55     Citation Subset:  IM    
Sikls Department of Pathological Anatomy, Charles University, Pilsen, Czech Republic.
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MeSH Terms
Biological Markers
Hamartoma / metabolism,  pathology*,  ultrastructure
Thoracic Neoplasms / metabolism,  pathology*
Thymoma / metabolism,  pathology*,  ultrastructure
Reg. No./Substance:
0/Biological Markers

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