Document Detail


Pitfalls in the diagnosis of ectopic hamartomatous thymoma.
MedLine Citation:
PMID:  8971562     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We describe four cases of ectopic hamartomatous thymoma with unusual morphological features. In cases 1 and 2 we found a dysplastic glandular component which was often arranged in a cribriform pattern bridging several glandular spaces. In case 2 we found solid adenocarcinomatous areas with infiltrative edges. Case 3 showed widespread smooth muscle differentiation within the spindle epithelial cell component, the presence of multiple clear cell glands which contained a distinct myoepithelial layer and an overall picture which vaguely resembled a sclerosing adenosis of the breast. Case 4 contained frequent foci of multinucleated giant epithelial cells within the markedly cellular spindle cell component: it also showed multiple, hypocellular, myxoid areas containing eosinophilic cords and pearls of squamous cells, and resembled squamous cell carcinoma with a sarcomatoid spindle cell component. We could not find any evidence of a thymic origin or of thymic differentiation in our four cases or in any other reported cases of ectopic hamartomatous thymoma. We believe that ectopic hamartomatous thymomas manifest salivary gland differentiation.
Authors:
M Michal; M Zámecník; M Gogora; P Mukensnabl; L Neubauer
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Histopathology     Volume:  29     ISSN:  0309-0167     ISO Abbreviation:  Histopathology     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-03-11     Completed Date:  1997-03-11     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7704136     Medline TA:  Histopathology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  549-55     Citation Subset:  IM    
Affiliation:
Sikls Department of Pathological Anatomy, Charles University, Pilsen, Czech Republic.
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers
Clavicle
Hamartoma / metabolism,  pathology*,  ultrastructure
Humans
Immunohistochemistry
Male
Sternum
Thoracic Neoplasms / metabolism,  pathology*
Thymoma / metabolism,  pathology*,  ultrastructure
Chemical
Reg. No./Substance:
0/Biological Markers

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