| Pitavastatin reduces elevated IL-18 levels in Japanese subjects with hypercholesterolemia: sub-analysis of Kansai investigation of statin for hyperlipidemic intervention in metabolism and endocrinology (KISHIMEN). | |
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MedLine Citation:
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PMID: 20940516 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: Pitavastatin significantly improved lipid profiles and reduced serum high-sensitivity C-reactive protein (hs-CRP) levels in a multi-center and prospective study. The aim of this study was to explore the effect of pitavastatin on serum levels of another inflammatory biomarker, interleukin-18 (IL-18), in a sub-analysis of the previous multi-center prospective study. METHODS: The subjects were 83 patients derived from the KISHIMEN study. Pitavastatin (1-2 mg/day) was administered for 12 months. Serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), remnant-like particle cholesterol (RLP-C), triglycerides (TG), IL-18, and high sensitivity C-reactive protein (hs-CRP) levels were measured. RESULTS: TC, LDL-C, and RLP-C levels were significantly reduced by 18.3%, 30.1%, and 21.0% (mean values) at 12 months after pitavastatin administration. TG levels were decreased by 9.8% in subjects whose basal TG levels were above 150 mg/dL. HDL-C levels were significantly increased at 6 months (11.9%). Pitavastatin did not significantly alter IL-18 levels in overall subjects, but reduced IL-18 levels in the highest quartile by 24.5% (median value) at 12 months. Pitavastatin significantly reduced hs-CRP levels by 28.6% in overall subjects and by 62.4% in the highest quartile at 12 months. There was a significant correlation between IL-18 and hs-CRP at baseline after both values were transformed into logarithms (Pearson's correlation coefficient, r = 0.259, p = 0.0181); however, percent changes in these levels were not significantly correlated. CONCLUSION: Pitavastatin significantly improves lipid profiles, and reduces enhanced inflammation monitored by IL-18, as well as by hs-CRP, in hypercholesterolemic subjects. |
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Authors:
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Yoshio Fujioka; Akira Fukuda; Tatsuro Ishida; Shinji Kagimoto; Yoshio Nakamura; Akane Iwakura; Kyoko Hara; Taizo Yamamoto; Akira Kuroe; Michihiro Ohya; Shinpei Fujimoto; Yoshiyuki Hamamoto; Sachiko Honjo; Hiroki Ikeda; Koichiro Nabe; Kinsuke Tsuda; Ataru Taniguchi; Kiyoshi Tanaka; Hiroyuki Koshiyama; Noriaki Kume; Ken-ichi Hirata |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study Date: 2010-10-06 |
Journal Detail:
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Title: Journal of atherosclerosis and thrombosis Volume: 18 ISSN: 1880-3873 ISO Abbreviation: J. Atheroscler. Thromb. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-02-01 Completed Date: 2011-05-31 Revised Date: 2011-08-16 |
Medline Journal Info:
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Nlm Unique ID: 9506298 Medline TA: J Atheroscler Thromb Country: Japan |
Other Details:
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Languages: eng Pagination: 8-15 Citation Subset: IM |
Affiliation:
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Division of Clinical Nutrition, Faculty of Nutrition, Kobe Gakuin University, Kobe, Japan. fujioka@nutr.kobegakuin.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use* Hypercholesterolemia / blood, drug therapy* Interleukin-18 / blood* Japan Male Middle Aged Prospective Studies Quinolines / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Interleukin-18; 0/Quinolines; 147511-69-1/pitavastatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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