| Pitavastatin inhibits hepatic steatosis and fibrosis in non-alcoholic steatohepatitis model rats. | |
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MedLine Citation:
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PMID: 21276150 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aim: Non-alcoholic steatohepatitis (NASH) may progress to liver cirrhosis, and NASH patients with liver cirrhosis are at risk of developing hepatocellular carcinoma. Statins, 3-hydroxy-3-methyglutaryl-coenzyme A reductase inhibitors, are well known to reduce low-density lipoprotein cholesterol and reduce the incidence of coronary heart disease and other major vascular events by anti-inflammatory and antifibrotic effects, and antiproliferative properties in colorectal cancers have also been reported. Recently, statins have been reported to improve hepatic steatosis; however, the effect on fibrosis is controversial. Methods: The effects of pitavastatin (one of the strongest statins) were examined using a choline-deficient L-amino acid-defined (CDAA) diet liver fibrosis model. Results: Pitavastatin significantly attenuated increases in serum aspartate aminotransferase, alanine aminotransferase, hepatic steatosis, oxidative stress, pre-neoplastic lesions (glutathione S-transferase placental form-positive lesions), expression of cytokines, such as tumor necrosis factor-α and transforming growth factor-β1, and the expression of tissue inhibitor of metalloproteinase-1, tissue inhibitor of metalloproteinase-2 and type I procollagen genes followed by attenuating fibrosis of the liver of CDAA-fed rats. Conclusion: These results indicate that pitavastatin may inhibit steatosis, hepatic fibrosis and carcinogenesis in rat model of NASH. |
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Authors:
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Tomokatsu Miyaki; Shunsuke Nojiri; Noboru Shinkai; Atsunori Kusakabe; Kentaro Matsuura; Etsuko Iio; Satoru Takahashi; Ge Yan; Kazuo Ikeda; Takashi Joh |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-30 |
Journal Detail:
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Title: Hepatology research : the official journal of the Japan Society of Hepatology Volume: - ISSN: 1386-6346 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9711801 Medline TA: Hepatol Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 The Japan Society of Hepatology. |
Affiliation:
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Departments of Gastroenterology and MetabolismExperimental Pathology and Tumor BiologyCell Biology and Anatomy, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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