Document Detail


Pitavastatin reduces lectin-like oxidized low-density lipoprotein receptor-1 ligands in hypercholesterolemic humans.
MedLine Citation:
PMID:  20229124     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to determine the impact of pitavastatin on low-density lipoprotein cholesterol (LDL-C) and lectin-like oxidized LDL receptor-1 (LOX-1) in patients with hypercholesterolemia. Twenty-five hypercholesterolemic patients (8 male, 17 female; age 66 +/- 13, 21-80 years) who had not received anti-dyslipidemic agents and had LDL-C levels of more than 160 mg/dL were examined. Biochemical factors were measured at baseline and after treatment with pitavastatin (2 mg/day) for 6 months. Serum levels of LOX-1 with apolipoprotein B-100 particle ligand and a soluble form of LOX-1 (sLOX-1) were measured by ELISA. All subjects completed the study with no adverse side effects. Total-C (268 +/- 26 vs. 176 +/- 17 mg/dL), LDL-C (182 +/- 21 vs. 96 +/- 14 mg/dL), and LOX-1 ligand (867 +/- 452 vs. 435 +/- 262 ng/mL) were reduced with pitavastatin treatment (P < 0.0001 for each). Significant decreases in triacylglycerols were noted (P < 0.0001), but there were no changes in high-density lipoprotein cholesterol. After 6 months, there were no significant changes in high-sensitivity CRP or soluble LOX-1. At baseline, there were no significant correlations between LOX-1 ligand and either LDL-C or sLOX-1. The decrease in LOX-1 ligand was not correlated with the decrease in LDL-C, but was correlated with the decrease in sLOX-1 (r = 0.47, P < 0.05). In conclusion, pitavastatin therapy had beneficial effects on markers of oxidative stress in hypercholesterolemic subjects. Serum levels of LOX-1 ligand may be a useful biomarker of the pleiotropic effects of statins.
Authors:
Tetsuya Matsumoto; Masatoshi Fujita; Tatsuya Sawamura; Akemi Kakino; Yuko Sato; Yoshiko Fujita; Haruo Matsuda; Mamoru Nakanishi; Kagehiro Uchida; Izuru Nakae; Hiroshi Kanda; Akira Yoshida; Kunihisa Miwa; Hideki Hayashi; Kenichi Mitsunami; Minoru Horie
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2010-03-13
Journal Detail:
Title:  Lipids     Volume:  45     ISSN:  1558-9307     ISO Abbreviation:  Lipids     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-25     Completed Date:  2010-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  329-35     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Shiga 520-2192, Japan. tetsuyam@belle.shiga-med.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Anticholesteremic Agents / pharmacology,  therapeutic use
Biological Markers / blood,  metabolism
Cholesterol, LDL / blood
Down-Regulation / drug effects
Female
Humans
Hypercholesterolemia / blood*,  drug therapy
Ligands
Male
Middle Aged
Quinolines / pharmacology*,  therapeutic use
Scavenger Receptors, Class E / blood*
Young Adult
Chemical
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Biological Markers; 0/Cholesterol, LDL; 0/Ligands; 0/Quinolines; 0/Scavenger Receptors, Class E; 147526-32-7/NK 104

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