| Pistachio nut consumption and serum lipid levels. | |
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MedLine Citation:
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PMID: 17536125 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Clinical and epidemiological studies have reported the beneficial effects of tree nuts and peanuts on serum lipid levels. We studied the effects of consuming 15% of the daily caloric intake in the form of pistachio nuts on the lipid profiles of free-living human subjects with primary, moderate hypercholesterolemia (serum cholesterol greater than 210 mg/dL). METHODS: design: Randomized crossover trial. setting: Outpatient dietary counseling and blood analysis. subjects: 15 subjects with moderate hypercholesterolemia. intervention: Fours weeks of dietary modification with 15% caloric intake from pistachio nuts. Measures of Outcome: Endpoints were serum lipid levels of total cholesterol, HDL-C, LDL-C, VLDL-C, triglycerides and apolipoproteins A-1 and B-100. BMI, blood pressure, and nutrient intake (total energy, fat, protein, and fiber) were also measured at baseline, during, and after dietary intervention. RESULTS: No statistically significant differences were observed for total energy or percent of energy from protein, carbohydrate or fat. On the pistachio nut diet, a statistically significant decrease was seen for percent energy from saturated fat (mean difference, -2.7%; 95% CI, -5.4% to -0.08%; p = 0.04). On the pistachio nut diet, statistically significant increases were seen for percent energy from polyunsaturated fat (mean difference, 6.5%; 95% CI, 4.2% to 8.9%; p<.0001) and fiber intake (mean difference, 15 g; 95% CI, 8.4 g to 22 g; p = 0.0003). On the pistachio diet, statistically significant reductions were seen in TC/HDL-C (mean difference, -0.38; 95% CI, -0.57 to -0.19; p = 0.001), LDL-C/HDL-C (mean difference, -0.40; 95% CI, -0.66 to -0.15; p = 0.004), B-100/A-1 (mean difference, -0.11; 95% CI, -0.19 to -0.03; p = 0.009) and a statistically significant increase was seen in HDL-C (mean difference, 2.3; 95% CI, 0.48 to 4.0; p = 0.02). No statistically significant differences were seen for total cholesterol, triglycerides, LDL-C, VLDL-C, apolipoprotein A-1 or apolipoprotein B-100. No changes were observed in BMI or blood pressure. CONCLUSION: A diet consisting of 15% of calories as pistachio nuts (about 2-3 ounces per day) over a four week period can favorably improve some lipid profiles in subjects with moderate hypercholesterolemia and may reduce risk of coronary disease. |
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Authors:
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Michael J Sheridan; James N Cooper; Madeline Erario; Craig E Cheifetz |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the American College of Nutrition Volume: 26 ISSN: 0731-5724 ISO Abbreviation: J Am Coll Nutr Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-05-30 Completed Date: 2007-07-30 Revised Date: 2008-06-23 |
Medline Journal Info:
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Nlm Unique ID: 8215879 Medline TA: J Am Coll Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 141-8 Citation Subset: IM |
Affiliation:
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Department of Medicine, Inova Fairfax Hospital, Falls Church, VA 22042-3300, USA. michael.sheridan@inova.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apolipoprotein A-I
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blood Apolipoprotein B-100 / blood Blood Pressure Cholesterol / blood* Cholesterol, HDL / blood Cholesterol, LDL / blood Coronary Disease / blood, etiology Cross-Over Studies Energy Intake Female Humans Hypercholesterolemia / blood, complications, diet therapy* Lipids / blood* Male Middle Aged Pistacia* |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein A-I; 0/Apolipoprotein B-100; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipids; 57-88-5/Cholesterol |
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