| Pirprofen, naproxen and placebo in the treatment of primary dysmenorrhoea. | |
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MedLine Citation:
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PMID: 3327669 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a double-blind between-patient clinical trial, 82 patients were admitted to the study and after a preliminary period with placebo administered in single-blindness, they were divided into two groups: "placebo-responders" and "placebo non-responders". Responders were treated with pirprofen capsules (400 mg, b.i.d.) or placebo capsules b.i.d.; non-responders were treated with pirprofen capsules (400 mg, b.i.d.) or naproxen capsules (250 mg, b.i.d.) according to two different randomisation lists, for four menstrual cycles. A complete medical examination, including evaluation of associated symptomatology, menstrual flow entity and global efficacy, was performed after each cycle. In the responders group results were significantly better with pirprofen than with placebo after only the second cycle of treatment (p less than 0.01). In the non-responders group both treatments showed "good" or "excellent" results in more than 80% of patients in all cycles. In all patients there were no significant differences in the evaluation of the menstrual flow entity, of the associated symptomatology and of the number of side-effects. |
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Authors:
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M Marchini; L Fedele; U Garagiola; V Maresca |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Drugs under experimental and clinical research Volume: 13 ISSN: 0378-6501 ISO Abbreviation: Drugs Exp Clin Res Publication Date: 1987 |
Date Detail:
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Created Date: 1988-05-06 Completed Date: 1988-05-06 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7802135 Medline TA: Drugs Exp Clin Res Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 699-705 Citation Subset: IM |
Affiliation:
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Mangiagalli Clinic of Obstetrics and Gynaecology, University of Milan, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Inflammatory Agents, Non-Steroidal / adverse effects, therapeutic use* Clinical Trials as Topic Double-Blind Method Dysmenorrhea / drug therapy* Female Humans Naproxen / adverse effects, therapeutic use* Phenylpropionates / adverse effects, therapeutic use* Placebos Random Allocation |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Phenylpropionates; 0/Placebos; 22204-53-1/Naproxen; 31793-07-4/pirprofen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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